ArticlePloS one2014
Repair of microdamage in osteonal cortical bone adjacent to bone screw.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 39 citations in OpenAlex.
- Inter-implant distance correlated to different preparation protocol on cortical bone: an animal study.BMC oral health · 2025Article
- Numerical Simulation of Fluid Shear Stress Distribution in Microcracks of Trabecular Bone.Applied bionics and biomechanics · 2025Article
- Prediction of Bone Remodeling in Rat Caudal Vertebrae Based on Fluid-Solid Coupling Simulation.Annals of biomedical engineering · 2024Article
- Adaptive Image Segmentation Reveals Substantial Cortical Bone Remodeling During Early Fracture Repair.Computer methods in biomechanics and biomedical engineering. Imaging & visualization · 2024Article
- Osteon: Structure, Turnover, and Regeneration.Tissue engineering. Part B, Reviews · 2022Review
- Evaluation of Cortical Bone Microdamage and Primary Stability of Orthodontic Miniscrew Using a Human Bone Analogue.Materials (Basel, Switzerland) · 2021Article
- Association between anterior bone loss and anterior heterotopic ossification in hybrid surgery.BMC musculoskeletal disorders · 2020Article
- Gradient fluid shear stress regulates migration of osteoclast precursors.Cell adhesion & migration · 2019Article
- Mechanical regulation of bone formation and resorption around implants in a mouse model of osteopenic bone.Journal of the Royal Society, Interface · 2019Article
- Trabecular deformations during screw pull-out: a micro-CT study of lapine bone.Biomechanics and modeling in mechanobiology · 2017Article
- Article
- Response to Letter to the Editor, "Multiscale Analyses of the Bone-implant Interface".Journal of dental research · 2015Article
- Histomorphometric analysis of microcrack healing after the installation of mini-implants.Journal of periodontal & implant science · 2015Article
- Multiscale imaging of bone microdamage.Connective tissue research · 2015Review
- Changes in the mechanical properties and composition of bone during microdamage repair.PloS one · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Up to date, little is known about the repair mode of microdamage in osteonal cortical bone resulting from bone screw implantation. In this study, self-tapping titanium cortical bone screws were inserted into the tibial diaphyses of 24 adult male rabbits. The animals were sacrificed at 1 day, 2 weeks, 1 month and 2 months after surgery. Histomorphometric measurement and confocal microscopy were performed on basic fuchsin stained bone sections to examine the morphological characteristics of microdamage, bone resorption activity and spatial relationship between microdamage and bone resorption. Diffuse and linear cracks were coexisted in peri-screw bone. Intracortical bone resorption was significantly increased 2 weeks after screw installation and reach to the maximum at 1 month. There was no significant difference in bone resorption between 1-month and 2-months groups. Microdamage was significantly decreased within 1 month after surgery. Bone resorption was predisposed to occur in the region of <100 µm from the bone-screw interface, where had extensive diffuse damage mixed with linear cracks. Different patterns of resorption cavities appeared in peri-screw bone. These data suggest that 1) the complex microdamage composed of diffuse damage and linear cracks is a strong stimulator for initiating targeted bone remodeling; 2) bone resorption activities taking place on the surfaces of differently oriented Haversian and Volkmann canals work in a team for the repair of extensive microdamage; 3) targeted bone remodeling is a short-term reaction to microdamage and thereby it may not be able to remove all microdamage resulting from bone screw insertion.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.