ArticlePloS one2014
A pilot study exploring the use of breath analysis to differentiate healthy cattle from cattle experimentally infected with Mycobacterium bovis.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Biodetection of an odor signature in white-tailed deer associated with infection by chronic wasting disease prions.PloS one · 2024Article
- Non-Invasive Blood Pressure Tracking of Spontaneous Hypertension Rats Using an Electronic Nose.Sensors (Basel, Switzerland) · 2023Article
- Putative volatile biomarkers of bovine tuberculosis infection in breath, skin and feces of cattle.Molecular and cellular biochemistry · 2023Article
- Detection ofMicrobiology spectrum · 2023Article
- Article
- Biomarker Metabolites Discriminate between Physiological States of Field, Cave and White-nose Syndrome Diseased Bats.Sensors (Basel, Switzerland) · 2022Article
- Breath analysis for detection and trajectory monitoring of acute respiratory distress syndrome in swine.ERJ open research · 2022Article
- Preservation of vapor samples on adsorbent alumina capillaries and implications for field sampling.Journal of chromatography. A · 2021Article
- Detection of Paratuberculosis in Dairy Herds by Analyzing the Scent of Feces, Alveolar Gas, and Stable Air.Molecules (Basel, Switzerland) · 2021Article
- Application of Volatilome Analysis to the Diagnosis of Mycobacteria Infection in Livestock.Frontiers in veterinary science · 2021Review
- Volatile Cues Influence Host-Choice in Arthropod Pests.Animals : an open access journal from MDPI · 2020Review
- A Data-Driven Prediction Method for an Early Warning of Coccidiosis in Intensive Livestock Systems: A Preliminary Study.Animals : an open access journal from MDPI · 2020Article
- Volatile metabolomic signatures of rabies immunization in two mesocarnivore species.PLoS neglected tropical diseases · 2019Article
- Screening of Microbial Volatile Organic Compounds for Detection of Disease in Cattle: Development of Lab-scale Method.Scientific reports · 2019Article
- Article
- Persistent Spillback of Bovine Tuberculosis From White-Tailed Deer to Cattle in Michigan, USA: Status, Strategies, and Needs.Frontiers in veterinary science · 2018Review
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Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bovine tuberculosis, caused by Mycobacterium bovis, is a zoonotic disease of international public health importance. Ante-mortem surveillance is essential for control; however, current surveillance tests are hampered by limitations affecting ease of use or quality of results. There is an emerging interest in human and veterinary medicine in diagnosing disease via identification of volatile organic compounds produced by pathogens and host-pathogen interactions. The objective of this pilot study was to explore application of existing human breath collection and analysis methodologies to cattle as a means to identify M. bovis infection through detection of unique volatile organic compounds or changes in the volatile organic compound profiles present in breath. Breath samples from 23 male Holstein calves (7 non-infected and 16 M. bovis-infected) were collected onto commercially available sorbent cartridges using a mask system at 90 days post-inoculation with M. bovis. Samples were analyzed using gas chromatography-mass spectrometry, and chromatographic data were analyzed using standard analytical chemical and metabolomic analyses, principle components analysis, and a linear discriminant algorithm. The findings provide proof of concept that breath-derived volatile organic compound analysis can be used to differentiate between healthy and M. bovis-infected cattle.
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