ArticlePloS one2014
PalmPred: an SVM based palmitoylation prediction method using sequence profile information.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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34 citing papers in PubMed, 65 citations in OpenAlex.
- iPalmT: a new paradigm for palmitoyltransferase discovery via end-to-end deep learning.Oncogene · 2026Article
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- Recent Advances, Challenges, and Functional Applications of Protein Chemical Modification in the Food Industry.Foods (Basel, Switzerland) · 2025Review
- A Novel Synthetic Tag Induces Palmitoylation and Directs the Subcellular Localization of Target Proteins.Biomolecules · 2025Article
- S-acylation of CaChronic diseases and translational medicine · 2024Review
- Mechanisms and functions of protein S-acylation.Nature reviews. Molecular cell biology · 2024Review
- Unveiling the defensive role of Snakin-3, a member of the subfamily III of Snakin/GASA peptides in potatoes.Plant cell reports · 2024Article
- Machine Learning Approaches: Detecting the Disease Variants in Human-Exhaled Breath Biomarkers.ACS omega · 2024Article
- Palmitoylation of solute carriers.Biochemical pharmacology · 2023Review
- EnsembleDL-ATG: Identifying autophagy proteins by integrating their sequence and evolutionary information using an ensemble deep learning framework.Computational and structural biotechnology journal · 2023Article
- Post-Translational Modifications of G Protein-Coupled Receptors Control Cellular Signaling Dynamics in Space and Time.Pharmacological reviews · 2021Review
- BacEffluxPred: A two-tier system to predict and categorize bacterial efflux mediated antibiotic resistance proteins.Scientific reports · 2020Article
- SuccSite: Incorporating Amino Acid Composition and Informative k-spaced Amino Acid Pairs to Identify Protein Succinylation Sites.Genomics, proteomics & bioinformatics · 2020Article
- Rapid classification of group B Streptococcus serotypes based on matrix-assisted laser desorption ionization-time of flight mass spectrometry and machine learning techniques.BMC bioinformatics · 2019Article
- Multiscale Simulations of Biological Membranes: The Challenge To Understand Biological Phenomena in a Living Substance.Chemical reviews · 2019Article
- Characterization and identification of lysine glutarylation based on intrinsic interdependence between positions in the substrate sites.BMC bioinformatics · 2019Article
- Polycystin-1, the product of the polycystic kidney disease gene PKD1, is post-translationally modified by palmitoylation.Molecular biology reports · 2018Article
- Extensive molecular tinkering in the evolution of the membrane attachment mode of the Rheb GTPase.Scientific reports · 2018Article
- Article
- MDD-carb: a combinatorial model for the identification of protein carbonylation sites with substrate motifs.BMC systems biology · 2017Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Protein palmitoylation is the covalent attachment of the 16-carbon fatty acid palmitate to a cysteine residue. It is the most common acylation of protein and occurs only in eukaryotes. Palmitoylation plays an important role in the regulation of protein subcellular localization, stability, translocation to lipid rafts and many other protein functions. Hence, the accurate prediction of palmitoylation site(s) can help in understanding the molecular mechanism of palmitoylation and also in designing various related experiments. Here we present a novel in silico predictor called 'PalmPred' to identify palmitoylation sites from protein sequence information using a support vector machine model. The best performance of PalmPred was obtained by incorporating sequence conservation features of peptide of window size 11 using a leave-one-out approach. It helped in achieving an accuracy of 91.98%, sensitivity of 79.23%, specificity of 94.30%, and Matthews Correlation Coefficient of 0.71. PalmPred outperformed existing palmitoylation site prediction methods - IFS-Palm and WAP-Palm on an independent dataset. Based on these measures it can be anticipated that PalmPred will be helpful in identifying candidate palmitoylation sites. All the source datasets, standalone and web-server are available at http://14.139.227.92/mkumar/palmpred/.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.