ArticlePloS one2014
Risk factors for hospital admission with RSV bronchiolitis in England: a population-based birth cohort study.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03436225 (Steroid Therapy in Acute Bronchiolitis A New Old Line of Therapy.), which is not on this map. Cited by 102 papers, 7 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Steroid Therapy in Acute Bronchiolitis A New Old Line of Therapy.
Who cites it
102 citing papers in PubMed, 7 syntheses or guidelines pooled it, 203 citations in OpenAlex.
- Pooled it
- Pooled it
- Parenteral versus enteral fluid therapy for children hospitalised with bronchiolitis.The Cochrane database of systematic reviews · 2021Pooled it
- Hospital utilization rates for influenza and RSV: a novel approach and critical assessment.Population health metrics · 2021Pooled it
- Magnesium sulphate for treating acute bronchiolitis in children up to two years of age.The Cochrane database of systematic reviews · 2020Pooled it
- Hypertonic saline (HS) for acute bronchiolitis: Systematic review and meta-analysis.BMC pulmonary medicine · 2015Pooled it
- The REporting of studies Conducted using Observational Routinely-collected health Data (RECORD) statement.PLoS medicine · 2015Guideline
- A phase I, randomized, placebo-controlled trial to evaluate the pharmacokinetics, safety, and tolerability of nirsevimab in healthy Chinese adults.Clinical and translational science · 2025Trial
- Phase 1/2a Safety and Immunogenicity of an Adenovirus 26 Vector Respiratory Syncytial Virus (RSV) Vaccine Encoding Prefusion F in Adults 18-50 Years and RSV-Seropositive Children 12-24 Months.The Journal of infectious diseases · 2022Trial
- A Randomized Phase 1/2 Study of a Respiratory Syncytial Virus Prefusion F Vaccine.The Journal of infectious diseases · 2022Trial
- Epidemiological and Clinical Characteristics of Bronchiolitis and the Impact of RSV Infection: A Five-Year Study in a Tertiary Pediatric Center in Central Romania.Pediatric reports · 2026Article
- Air pollution and the risk of bronchiolitis-related hospital admission in a birth cohort of over 400,000 children born in London.Environmental epidemiology (Philadelphia, Pa.) · 2026Article
- Trends in Hospitalisations Due to Respiratory Syncytial Virus in Swedish Children: A Nationwide Study 2010-2022.Acta paediatrica (Oslo, Norway : 1992) · 2026Article
- Preventable Infectious Pathology Dominates Neonatal Readmissions: A Retrospective Analysis from a Pediatrics Department in Ploiești, Romania.Children (Basel, Switzerland) · 2026Article
- Evaluating the impact of a parent champion model on bronchiolitis hospitalisation rates: a difference in differences study.Archives of disease in childhood · 2026Article
- Observational
- Modeling the greenhouse gas emissions of an immunization program against respiratory syncytial virus in infants in the United Kingdom.International journal of technology assessment in health care · 2025Article
- Efficacy and Safety of Anti-Respiratory Syncytial Virus Monoclonal Antibody Nirsevimab in Neonates: A Real-World Monocentric Study.Vaccines · 2025Article
- Hospitalizations for respiratory syncytial virus (RSV) in Sicily from 2008 to 2021: clinical features and predictors of severity.Italian journal of pediatrics · 2025Article
- Epidemiological and Clinical Characteristics of Respiratory Syncytial Virus Infection in Children in Hangzhou (2022-2023).Pathogens (Basel, Switzerland) · 2025Article
42 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveTo examine the timing and duration of RSV bronchiolitis hospital admission among term and preterm infants in England and to identify risk factors for bronchiolitis admission.
designA population-based birth cohort with follow-up to age 1 year, using the Hospital Episode Statistics database.
setting71 hospitals across England.
participantsWe identified 296618 individual birth records from 2007/08 and linked to subsequent hospital admission records during the first year of life.
resultsIn our cohort there were 7189 hospital admissions with a diagnosis of bronchiolitis, 24.2 admissions per 1000 infants under 1 year (95%CI 23.7-24.8), of which 15% (1050/7189) were born preterm (47.3 bronchiolitis admissions per 1000 preterm infants (95% CI 44.4-50.2)). The peak age group for bronchiolitis admissions was infants aged 1 month and the median was age 120 days (IQR = 61-209 days). The median length of stay was 1 day (IQR = 0-3). The relative risk (RR) of a bronchiolitis admission was higher among infants with known risk factors for severe RSV infection, including those born preterm (RR = 1.9, 95% CI 1.8-2.0) compared with infants born at term. Other conditions also significantly increased risk of bronchiolitis admission, including Down's syndrome (RR = 2.5, 95% CI 1.7-3.7) and cerebral palsy (RR = 2.4, 95% CI 1.5-4.0).
conclusionsMost (85%) of the infants who are admitted to hospital with bronchiolitis in England are born at term, with no known predisposing risk factors for severe RSV infection, although risk of admission is higher in known risk groups. The early age of bronchiolitis admissions has important implications for the potential impact and timing of future active and passive immunisations. More research is needed to explain why babies born with Down's syndrome and cerebral palsy are also at higher risk of hospital admission with RSV bronchiolitis.
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