SynthesisPloS one2014
Effects of physician-nurse substitution on clinical parameters: a systematic review and meta-analysis.
Synthesis in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 4 syntheses or guidelines pooled it, 75 citations in OpenAlex.
- Task shifting in primary care to tackle healthcare worker shortages: An umbrella review.The European journal of general practice · 2021Pooled it
- Barriers and facilitators to the implementation of doctor-nurse substitution strategies in primary care: a qualitative evidence synthesis.The Cochrane database of systematic reviews · 2019Pooled it
- Nurses as substitutes for doctors in primary care.The Cochrane database of systematic reviews · 2018Pooled it
- Delivery arrangements for health systems in low-income countries: an overview of systematic reviews.The Cochrane database of systematic reviews · 2017Pooled it
- Trial
- Team-based care for improving hypertension management among outpatients (TBC-HTA): study protocol for a pragmatic randomized controlled trial.BMC cardiovascular disorders · 2017Trial
- The impact of substituting general practitioners with nurse practitioners on resource use, production and health-care costs during out-of-hours: a quasi-experimental study.BMC family practice · 2016Trial
- Adherence to Competing Strategies for Colorectal Cancer Screening Over 3 Years.The American journal of gastroenterology · 2016Trial
- Collaborative Primary-Care Workforce Models: An Integrative Review of Evidence Informing RN Prescriber Integration with Family Physicians and Nurse Practitioners.Healthcare (Basel, Switzerland) · 2026Review
- A Health Systems Approach to Nurse-Led Implementation of Diabetes Prevention and Management in Vulnerable Populations.Health systems and reform · 2025Article
- Skill mix in primary care, working hours, time used on management, and burnout among general practitioners.Family practice · 2025Article
- Nurse-Managed Hypertension Care in Primary Health Care Centers in Region Stockholm and Its Association With Blood Pressure Control and Key Indicators for Contractual Follow-Up.Journal of clinical hypertension (Greenwich, Conn.) · 2025Article
- Article
- Effects of task-shifting from primary care physicians to nurses: an overview of systematic reviews.Human resources for health · 2024Review
- The Influence of Nurse-Led Interventions on Diseases Management in Patients with Diabetes Mellitus: A Narrative Review.Healthcare (Basel, Switzerland) · 2024Review
- A global perspective of advanced practice nursing research: A review of systematic reviews.PloS one · 2024Review
- A situational analysis of human resource and non-communicable diseases management for community health workers in Chengdu, China: a cross-sectional study.BMC health services research · 2023Article
- Identifying indicators sensitive to primary healthcare nurse practitioner practice: A review of systematic reviews.PloS one · 2023Review
- Regional inequalities and substitutability of health resources in the Czech Republic: a five methods of evaluation.Human resources for health · 2021Article
- Outcomes of primary care delivery by nurse practitioners: Utilization, cost, and quality of care.Health services research · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPhysicians' shortage in many countries and demands of high-quality and affordable care make physician-nurse substitution an appealing workforce strategy. The objective of this study is to conduct a systematic review and meta-analysis of randomised controlled trials (RCTs) assessing the impact of physician-nurse substitution in primary care on clinical parameters.
methodsWe systematically searched OVID Medline and Embase, The Cochrane Library and CINAHL, up to August 2012; selected peer-reviewed RCTs comparing physician-led care with nurse-led care on changes in clinical parameters. Study selection and data extraction were performed in duplicate by independent reviewers. We assessed the individual study risk of bias; calculated the study-specific and pooled relative risks (RR) or weighted mean differences (WMD); and performed fixed-effects meta-analyses.
results11 RCTs (N = 30,247) were included; most were from Europe, generally small with higher risk of bias. In all studies, nurses provided care for complex conditions including HIV, hypertension, heart failure, cerebrovascular diseases, diabetes, asthma, Parkinson's disease and incontinence. Meta-analyses showed greater reductions in systolic blood pressure (SBP) in favour of nurse-led care (WMD -4.27 mmHg, 95% CI -6.31 to -2.23) but no statistically significant differences between groups in the reduction of diastolic blood pressure (DBP) (WMD -1.48 mmHg, 95%CI -3.05 to -0.09), total cholesterol (TC) (WMD -0.08 mmol/l, 95%CI -0.22 to 0.07) or glycosylated haemoglobin (WMD 0.12%HbAc1, 95%CI -0.13 to 0.37). Of other 32 clinical parameters identified, less than a fifth favoured nurse-led care while 25 showed no significant differences between groups. LIMITATIONS: disease-specific interventions from a small selection of healthcare systems, insufficient quantity and quality of studies, many different parameters.
conclusionstrained nurses appeared to be better than physicians at lowering SBP but similar at lowering DBP, TC or HbA1c. There is insufficient evidence that nurse-led care leads to better outcomes of other clinical parameters than physician-led care.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.