ArticlePloS one2014
Genomic characterization of novel Listeria monocytogenes serotype 4b variant strains.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Genomic epidemiology of the clinically dominant clonal complex 1 in theMicrobial genomics · 2024Article
- Identification ofPathogens (Basel, Switzerland) · 2023Article
- Conditions of In Vitro Biofilm Formation by Serogroups ofFoods (Basel, Switzerland) · 2021Article
- Molecular Typing ofPathogens (Basel, Switzerland) · 2021Article
- Analysis of virulence genes and molecular typing of Listeria monocytogenes isolates from human, food, and livestock from 2008 to 2016 in Iran.Tropical animal health and production · 2021Article
- A review of Listeria monocytogenes from meat and meat products: Epidemiology, virulence factors, antimicrobial resistance and diagnosis.The Onderstepoort journal of veterinary research · 2020Review
- Whole-genome sequencing ofNew microbes and new infections · 2020Article
- Genomic Diversity of Common Sequence Types ofGenes · 2019Article
- Current Trends in Foodborne Human Listeriosis.Food safety (Tokyo, Japan) · 2018Review
- A Comprehensive Evaluation of the Genetic Relatedness ofFrontiers in public health · 2017Article
- Article
- Prospective Whole-Genome Sequencing Enhances National Surveillance of Listeria monocytogenes.Journal of clinical microbiology · 2016Article
- Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Over 90% of the human listeriosis cases are caused by Listeria monocytogenes serotypes 1/2a, 1/2b and 4b strains. As an alternative to antigen-antibody based serotyping, a PCR-based method for serogrouping has been developed and validated. In this communication, we report an in-depth analysis of five 4b variant strains, four clinical isolates from Australia and one environmental isolate from USA. Although these five strains were serotype 4b by classical serotyping method, the serogrouping PCR profiles of these strains show the presence of a 1/2a-3a specific amplicon in addition to the standard 4b-4d-4e specific amplicons. These strains were further analyzed by pulsed field gel electrophoresis, binary gene typing, multi-locus variable-number-tandem-repeat analysis and a high density pan-genomic Listeria microarray. Using these sub-typing results, the clinical isolates were grouped into two distinct genomic groups- one of which could be part of an unidentified outbreak. The microarray results when compared with our database of other 4b outbreak isolates indicated that the serotype 4b variant strains represent very different genotypic profiles than the known reported 4b outbreak strains representing major epidemic clones. The acquisition of serotype 1/2a gene clusters by the 4b variant strains appears to be independent in origin, spanning large areas of geographical and temporal space and may indicate predisposition of some 4b strains towards accepting DNA from related organisms.
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