Evidence map›Paper›PMID 24586437›Full record

SynthesisPloS one2014

Prognostic value of perineural invasion in gastric cancer: a systematic review and meta-analysis.

Jing Deng, Qihan You, Yang Gao, Qing Yu, Peng Zhao, Yulong Zheng, Weijia Fang, Nong Xu, Lisong Teng

Open access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
81citing papers in PubMed, 3 pooled it
3.9field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

81 citing papers in PubMed, 3 syntheses or guidelines pooled it, 124 citations in OpenAlex.

  1. Pooled it
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  3. Prognostic value of perineural invasion in colorectal cancer: a meta-analysis.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2015
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  6. Nodal burden modifies the prognostic significance of perineural invasion in stage I-III gastric cancer.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2026
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21 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Jing DengDepartment of Medical Oncology, The First Hospital Affiliated to Medical School of Zhejiang University, Hangzhou, China.
Qihan YouDepartment of Pathology, The First Hospital Affiliated to Medical School of Zhejiang University, Hangzhou, China.
Yang GaoMedical School of Zhejiang University, Hangzhou, China.
Qing YuMedical School of Zhejiang University, Hangzhou, China.
Peng ZhaoDepartment of Medical Oncology, The First Hospital Affiliated to Medical School of Zhejiang University, Hangzhou, China.
Yulong ZhengDepartment of Medical Oncology, The First Hospital Affiliated to Medical School of Zhejiang University, Hangzhou, China.
Weijia FangDepartment of Medical Oncology, The First Hospital Affiliated to Medical School of Zhejiang University, Hangzhou, China.
Nong XuDepartment of Medical Oncology, The First Hospital Affiliated to Medical School of Zhejiang University, Hangzhou, China.
Lisong TengDepartment of Surgical Oncology, The First Hospital Affiliated to Medical School of Zhejiang University, Hangzhou, China.
Zhejiang University · CNZhejiang Chinese Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe prognostic role of perineural invasion in gastric cancer is controversial. Here, we present a systemic review and meta-analysis of the association between perineural invasion and survival in resectable gastric cancer patients.

methodsA comprehensive literature search for relevant reports published up to April 2013 was performed using PubMed, Embase, Web of Science and Wanfang Data. Studies that investigated the role of perineural invasion with a sample size greater than 100 were included and analyzed.

resultsA total of 30,590 gastric cancer patients who had undergone curative gastrectomy from twenty-four studies were included. The median rate of perineural invasion positive was 40.9% (6.8%-75.6%). Fourteen studies investigated overall survival unadjusted for other variables in 23,233 gastric cancer patients. The relative hazard estimates ranged from 0.568-7.901 with a combined random effects estimate of 2.261 (95% CI = 1.841-2.777, P = 0.000). The effect of perineural invasion on overall survival adjusted for other prognostic factors was reported in 17 studies incorporating 8,551 cases. The hazard estimates ranged from 0.420-8.110 with a pooled random effects estimates of 1.484 (95% CI = 1.237-1.781, P = 0.000). There was heterogeneity between the studies (Q = 49.22, I-squared = 67.5%, P = 0.000). Disease-free survival was investigated adjusted in four studies incorporating 9,083 cases and the pooled fixed hazard ratio estimate was 1.371(95% CI = 1.230-1.527, P = 0.000).

conclusionPerineural invasion is an independent prognostic factor affecting overall survival and disease-free survival of gastric cancer patients who had undergone the curative resection. This effect is independent of lymph node status, tumor size and the depth of invasion as well as a range of other biological variables on multivariate analysis. Large prospective studies are now needed to establish perineural invasion as an independent prognostic marker for gastric cancer.

Indexed as

GastrectomyHumansLymphatic MetastasisModels, StatisticalNeoplasm InvasivenessPeripheral NervesPrognosisProportional Hazards ModelsRetrospective StudiesStomach Neoplasms

Identifiers

PMID24586437
PMCPMC3931634
OpenAlexW2030430663

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.