ArticlePloS one2014
Evaluation of the efficacy and safety of a marine-derived Bacillus strain for use as an in-feed probiotic for newly weaned pigs.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Marine-DerivedInternational journal of molecular sciences · 2026Review
- In vitro compatibility screening of Bacillus pumilus and Bacillus altitudinis strains with selected candidate prebiotics for in ovo application of synergistic synbiotics.Applied microbiology and biotechnology · 2025Article
- Evaluating the effects of direct-fed microbial supplementation on the performance, milk quality and fatty acid of mid-lactating dairy cows.Veterinary medicine and science · 2023Article
- Maternal and/or post-weaning supplementation with Bacillus altitudinis spores modulates the microbial composition of colostrum, digesta and faeces in pigs.Scientific reports · 2023Article
- Intestinal microbiota modulation and improved growth in pigs with post-weaning antibiotic and ZnO supplementation but only subtle microbiota effects with Bacillus altitudinis.Scientific reports · 2021Article
- Maximum levels of cross-contamination for 24 antimicrobial active substances in non-target feed. Part 2:EFSA journal. European Food Safety Authority · 2021Article
- Effects ofAnimals : an open access journal from MDPI · 2020Article
- Feeding differing direct-fed microbials and its influence on growth and haematological parameters of growing lambs.Translational animal science · 2019Article
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- Article
- Dietary ZnO nanoparticles alters intestinal microbiota and inflammation response in weaned piglets.Oncotarget · 2017Article
- Exploring a Possible Link between the Intestinal Microbiota and Feed Efficiency in Pigs.Applied and environmental microbiology · 2017Article
- Dimethyl fumarate reduces the risk of mycotoxins via improving intestinal barrier and microbiota.Oncotarget · 2017Article
- In vitro assessment of marine Bacillus for use as livestock probiotics.Marine drugs · 2014Article
- Article
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Forty eight individual pigs (8.7±0.26 kg) weaned at 28±1 d of age were used in a 22-d study to evaluate the effect of oral administration of a Bacillus pumilus spore suspension on growth performance and health indicators. Treatments (n = 16) were: (1) non-medicated diet; (2) medicated diet with apramycin (200 mg/kg) and pharmacological levels of zinc oxide (2,500 mg zinc/kg) and (3) B. pumilus diet (non-medicated diet + 10(10) spores/day B. pumilus). Final body weight and average daily gain tended to be lower (P = 0.07) and feed conversion ratio was worsened (P<0.05) for the medicated treatment compared to the B. pumilus treatment. Ileal E. coli counts were lower for the B. pumilus and medicated treatments compared to the non-medicated treatment (P<0.05), perhaps as a result of increased ileal propionic acid concentrations (P<0.001). However, the medicated treatment reduced fecal (P<0.001) and cecal (P<0.05) Lactobacillus counts and tended to reduce the total cecal short chain fatty acid (SCFA) concentration (P = 0.10). Liver weights were lighter and concentrations of liver enzymes higher (P<0.05) in pigs on the medicated treatment compared to those on the non-medicated or B. pumilus treatments. Pigs on the B. pumilus treatment had lower overall lymphocyte and higher granulocyte percentages (P<0.001) and higher numbers of jejunal goblet cells (P<0.01) than pigs on either of the other two treatments or the non-medicated treatment, respectively. However, histopathological examination of the small intestine, kidneys and liver revealed no abnormalities. Overall, the B. pumilus treatment decreased ileal E. coli counts in a manner similar to the medicated treatment but without the adverse effects on growth performance, Lactobacillus counts, cecal SCFA concentration and possible liver toxicity experienced with the medicated treatment.
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