ArticlePloS one2014
Changes in intestinal glucocorticoid sensitivity in early life shape the risk of epithelial barrier defect in maternal-deprived rats.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed, 75 citations in OpenAlex.
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- Effect of diet supplemented with functional amino acids and polyphenols on gut health in broilers subjected to a corticosterone-induced stress.Scientific reports · 2024Article
- A review of the pathogenesis of epilepsy based on the microbiota-gut-brain-axis theory.Frontiers in molecular neuroscience · 2024Review
- Composition of gut microbiota involved in alleviation of dexamethasone-induced muscle atrophy by whey protein.NPJ science of food · 2023Article
- The potential of the gut microbiome for identifying Alzheimer's disease diagnostic biomarkers and future therapies.Frontiers in neuroscience · 2023Review
- Article
- Gut microbiome in schizophrenia and antipsychotic-induced metabolic alterations: a scoping review.Therapeutic advances in psychopharmacology · 2022Article
- Importance of crosstalk between the microbiota and the neuroimmune system for tissue homeostasis.Clinical & translational immunology · 2022Review
- Recent Advances in Understanding the Structure and Function of the Human Microbiome.Frontiers in microbiology · 2022Review
- A Microbiome-Driven Approach to Combating Depression During the COVID-19 Pandemic.Frontiers in nutrition · 2021Article
- The microbiota-gut-brain axis: An emerging role for the epigenome.Experimental biology and medicine (Maywood, N.J.) · 2020Review
- Effect of Xiaoyaosan on Colon Morphology and Intestinal Permeability in Rats With Chronic Unpredictable Mild Stress.Frontiers in pharmacology · 2020Article
- Psychological Stress, Intestinal Barrier Dysfunctions, and Autoimmune Disorders: An Overview.Frontiers in immunology · 2020Review
- Barbaloin Attenuates Mucosal Damage in Experimental Models of Rat Colitis by Regulating Inflammation and the AMPK Signaling Pathway.Medical science monitor : international medical journal of experimental and clinical research · 2019Article
- Early life nutrition influences susceptibility to chronic inflammatory colitis in later life.Scientific reports · 2019Article
- Pharmacological restoration of gut barrier function in stressed neonates partially reverses long-term alterations associated with maternal separation.Psychopharmacology · 2019Article
- From Probiotics to Psychobiotics: Live Beneficial Bacteria Which Act on the Brain-Gut Axis.Nutrients · 2019Review
- Finding the needle in the haystack: systematic identification of psychobiotics.British journal of pharmacology · 2018Review
- Effect of probiotic Bifidobacterium bifidum G9-1 on the relationship between gut microbiota profile and stress sensitivity in maternally separated rats.Scientific reports · 2018Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Glucocorticoids (GC) contribute to human intestine ontogeny and accelerate gut barrier development in preparation to birth. Rat gut is immature at birth, and high intestinal GC sensitivity during the first two weeks of life resembles that of premature infants. This makes suckling rats a model to investigate postpartum impact of maternal separation (MS)-associated GC release in preterm babies, and whether GC sensitivity may shape MS effects in immature gut. A 4 hours-MS applied once at postnatal day (PND)10 enhanced plasma corticosterone in male and female pups, increased by two times the total in vivo intestinal permeability (IP) to oral FITC-Dextran 4 kDa (FD4) immediately after the end of MS, and induced bacterial translocation (BT) to liver and spleen. Ussing chamber experiments demonstrated a 2-fold increase of permeability to FD4 in the colon immediately after the end of MS, but not in the ileum. Colonic permeability was not only increased for FD4 but also to intact horseradish peroxidase 44 kDa in MS pups. In vivo, the glucocorticoid receptor (GR) antagonist RU486 or ML7 blockade of myosin light chain kinase controlling epithelial cytoskeleton contraction prevented MS-induced IP increase to oral FD4 and BT. In addition, the GR agonist dexamethasone dose-dependently mimicked MS-increase of IP to oral FD4. In contrast, MS effects on IP to oral FD4 and BT were absent at PND20, a model for full-term infant, characterized by a marked drop of IP to FD4 in response to dexamethasone, and decreased GR expression in the colon only compared to PND10 pups. These results show that high intestinal GC responsiveness in a rat model of prematurity defines a vulnerable window for a post-delivery MS, evoking immediate disruption of epithelial integrity in the large intestine, and increasing susceptibility to macromolecule passage and bacteremia.
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