ArticlePloS one2014
Accurate and robust prediction of genetic relationship from whole-genome sequences.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed.
- READv2: advanced and user-friendly detection of biological relatedness in archaeogenomics.Genome biology · 2024Article
- correctKin: an optimized method to infer relatedness up to the 4th degree from low-coverage ancient human genomes.Genome biology · 2023Article
- KIN: a method to infer relatedness from low-coverage ancient DNA.Genome biology · 2023Article
- A rare loss-of-function variant of ADAM17 is associated with late-onset familial Alzheimer disease.Molecular psychiatry · 2020Article
- Identity by descent analysis identifies founder events and linksNPJ genomic medicine · 2020Article
- Ancient genome-wide analyses infer kinship structure in an Early Medieval Alemannic graveyard.Science advances · 2018Article
- RareNeurology. Genetics · 2018Article
- Article
- Quickly identifying identical and closely related subjects in large databases using genotype data.PloS one · 2017Article
- Strategies for determining kinship in wild populations using genetic data.Ecology and evolution · 2016Review
- A novel Fanconi anaemia subtype associated with a dominant-negative mutation in RAD51.Nature communications · 2015Article
- One Size Doesn't Fit All - RefEditor: Building Personalized Diploid Reference Genome to Improve Read Mapping and Genotype Calling in Next Generation Sequencing Studies.PLoS computational biology · 2015Article
- Determining the genome-wide kinship coefficient seems unhelpful in distinguishing consanguineous couples with a high versus low risk for adverse reproductive outcome.BMC medical genetics · 2015Article
- Mutations in NOTCH1 cause Adams-Oliver syndrome.American journal of human genetics · 2014Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Computing the genetic relationship between two humans is important to studies in genetics, genomics, genealogy, and forensics. Relationship algorithms may be sensitive to noise, such as that arising from sequencing errors or imperfect reference genomes. We developed an algorithm for estimation of genetic relationship by averaged blocks (GRAB) that is designed for whole-genome sequencing (WGS) data. GRAB segments the genome into blocks, calculates the fraction of blocks sharing identity, and then uses a classification tree to infer 1st- to 5th- degree relationships and unrelated individuals. We evaluated GRAB on simulated and real sequenced families, and compared it with other software. GRAB achieves similar performance, and does not require knowledge of population background or phasing. GRAB can be used in workflows for identifying unreported relationships, validating reported relationships in family-based studies, and detection of sample-tracking errors or duplicate inclusion. The software is available at familygenomics.systemsbiology.net/grab.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.