ArticlePloS one2014
Clinical analysis of cause, treatment and prognosis in acute kidney injury patients.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02530359 (Pirfenidone Effect on the Recovery of Renal Function in Patients With Septic Acute Kidney Injury), which is not on this map. Cited by 26 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Pirfenidone Effect on the Recovery of Renal Function in Patients With Septic Acute Kidney Injury
Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 52 citations in OpenAlex.
- The Japanese clinical practice guideline for acute kidney injury 2016.Clinical and experimental nephrology · 2018Guideline
- Amphotericin B deoxycholate versus liposomal amphotericin B: effects on kidney function.The Cochrane database of systematic reviews · 2015Pooled it
- Clinical Assessment of Fluid Status in Adults With Acute Kidney Injury: A Scoping Review.Journal of renal care · 2025Article
- Soluble average Klotho level as a prognostic marker for acute kidney injury outcomes: a 90-day follow-up study.Biomarkers in medicine · 2025Article
- Chronic Kidney Disease-Epidemiology Collaboration (CKD - EPI) classification of kidney function and predictors of kidney dysfunction among type 2 diabetes mellitus patients in a tertiary hospital in Ghana.The Pan African medical journal · 2024Article
- Identification of Pre-Renal and Intrinsic Acute Kidney Injury by Anamnestic and Biochemical Criteria: Distinct Association with Urinary Injury Biomarkers.International journal of molecular sciences · 2023Article
- Dynamics of necroptosis in kidney ischemia-reperfusion injury.Frontiers in immunology · 2023Article
- Efficacy of orally administered montmorillonite in myoglobinuric acute renal failure model in male rats.Iranian journal of basic medical sciences · 2023Article
- Review on kidney diseases: types, treatment and potential of stem cell therapy.Renal replacement therapy · 2023Review
- Diagnosis of Cardiac Surgery-Associated Acute Kidney Injury: State of the Art and Perspectives.Journal of clinical medicine · 2022Review
- The Urinary Level of Injury Biomarkers Is Not Univocally Reflective of the Extent of Toxic Renal Tubular Injury in Rats.International journal of molecular sciences · 2022Article
- Seasonal variation in the detection rate and all-cause in-hospital mortality of AKI in China: A nationwide cohort study.Frontiers in public health · 2022Article
- Mortality Prediction in Patients with Severe Acute Kidney Injury Requiring Renal Replacement Therapy.Medicina (Kaunas, Lithuania) · 2021Article
- Development and Validation of a Prediction Model for Survival in Diabetic Patients With Acute Kidney Injury.Frontiers in endocrinology · 2021Article
- Acute Kidney Injury in Patients Undergoing Cardiac Transplantation: A Meta-Analysis.Medicines (Basel, Switzerland) · 2019Article
- A prospective study of clinical characteristics and outcomes of acute kidney injury in a tertiary care Centre.BMC nephrology · 2019Article
- Assessment of Canine Pancreas-Specific Lipase and Outcomes in Dogs with Hemodialysis-Dependent Acute Kidney Injury.Journal of veterinary internal medicine · 2018Article
- The Japanese Clinical Practice Guideline for acute kidney injury 2016.Journal of intensive care · 2018Article
- Early lipid changes in acute kidney injury using SWATH lipidomics coupled with MALDI tissue imaging.American journal of physiology. Renal physiology · 2016Article
- Pyelonephritis and obstructive uropathy: a case of acute kidney injury.BMJ case reports · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acute kidney injury (AKI) is characterized by an abrupt decline in renal function, resulting in an inability to secrete waste products and maintain electrolyte and water balance, and is associated with high risks of morbidity and mortality. This study retrospectively analyzed clinical data, treatment, and prognosis of 271 hospitalized patients (172 males and 99 females) diagnosed with AKI from December, 2008 to December, 2011. In addition, this study explored the association between the cause of AKI and prognosis, severity and treatment of AKI. The severity of AKI was classified according to the Acute Kidney Injury Network (AKIN) criteria. Renal recovery was defined as a decrease in a serum creatinine level to the normal value. Prerenal, renal, and postrenal causes accounted for 36.5% (99 patients), 46.5% (126 patients) and 17.0% (46 patients), respectively, of the incidence of AKI. Conservative, surgical, and renal replacement treatments were given to 180 (66.4%), 30 (11.1%) and 61 patients (22.5%), respectively. The overall recovery rate was 21.0%, and the mortality rate was 19.6%. Levels of Cl(-), Na(+) and carbon dioxide combining power decreased with increasing severity of AKI. Cause and treatment were significantly associated with AKI prognosis. Likewise, the severity of AKI was significantly associated with cause, treatment and prognosis. Multivariate logistic regression analysis found that respiratory injury and multiple organ dysfunction syndrome (MODS) were associated with AKI patient death. Cause, treatment and AKIN stage are associated with the prognosis of AKI. Respiratory injury and MODS are prognostic factors for death of AKI patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.