ArticlePLoS genetics2014
Negative feedback and transcriptional overshooting in a regulatory network for horizontal gene transfer.
Article in PLoS genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 62 citations in OpenAlex.
- The extended mobility of plasmids.Nucleic acids research · 2025Review
- A plasmid-encoded inactive toxin-antitoxin system MtvT/MtvA regulates plasmid conjugative transfer and bacterial virulence in Pseudomonas aeruginosa.Nucleic acids research · 2025Article
- Encounter rates and engagement times limit the transmission of conjugative plasmids.PLoS genetics · 2025Article
- Antimicrobial resistance level and conjugation permissiveness shape plasmid distribution in clinical enterobacteria.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Dissemination of IncI plasmid encodingAntimicrobial agents and chemotherapy · 2023Article
- Evaporation-induced hydrodynamics control plasmid transfer during surface-associated microbial growth.NPJ biofilms and microbiomes · 2023Article
- Tradeoff between lag time and growth rate drives the plasmid acquisition cost.Nature communications · 2023Article
- Structural basis of direct and inverted DNA sequence repeat recognition by helix-turn-helix transcription factors.Nucleic acids research · 2022Article
- Article
- Translational demand is not a major source of plasmid-associated fitness costs.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Article
- Harmful behaviour through plasmid transfer: a successful evolutionary strategy of bacteria harbouring conjugative plasmids.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Article
- Comment on "Indirect Fitness Benefits Enable the Spread of Host Genes Promoting Costly Transfer of Beneficial Plasmids".PLoS biology · 2021Article
- Conjugation dynamics depend on both the plasmid acquisition cost and the fitness cost.Molecular systems biology · 2021Article
- Unique Properties of the Alpha-Helical DNA-Binding Protein KfrA Encoded by the IncU Incompatibility Group Plasmid RA3 and Its Host-Dependent Role in Plasmid Maintenance.Applied and environmental microbiology · 2021Article
- Monitoring Bacterial Conjugation by Optical Microscopy.Frontiers in microbiology · 2021Article
- Biosolids as a Source of Antibiotic Resistance Plasmids for Commensal and Pathogenic Bacteria.Frontiers in microbiology · 2021Article
- A Framework for Implementing Metaheuristic Algorithms Using Intercellular Communication.Frontiers in bioengineering and biotechnology · 2021Article
- Molecular Mechanisms Influencing Bacterial Conjugation in the Intestinal Microbiota.Frontiers in microbiology · 2021Review
- Transcriptional Organization of the Stability Module of Broad-Host-Range Plasmid RA3, from the IncU Group.Applied and environmental microbiology · 2020Article
- ArdC, a ssDNA-binding protein with a metalloprotease domain, overpasses the recipient hsdRMS restriction system broadening conjugation host range.PLoS genetics · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Horizontal gene transfer (HGT) is a major force driving bacterial evolution. Because of their ability to cross inter-species barriers, bacterial plasmids are essential agents for HGT. This ability, however, poses specific requisites on plasmid physiology, in particular the need to overcome a multilevel selection process with opposing demands. We analyzed the transcriptional network of plasmid R388, one of the most promiscuous plasmids in Proteobacteria. Transcriptional analysis by fluorescence expression profiling and quantitative PCR revealed a regulatory network controlled by six transcriptional repressors. The regulatory network relied on strong promoters, which were tightly repressed in negative feedback loops. Computational simulations and theoretical analysis indicated that this architecture would show a transcriptional burst after plasmid conjugation, linking the magnitude of the feedback gain with the intensity of the transcriptional burst. Experimental analysis showed that transcriptional overshooting occurred when the plasmid invaded a new population of susceptible cells. We propose that transcriptional overshooting allows genome rebooting after horizontal gene transfer, and might have an adaptive role in overcoming the opposing demands of multilevel selection.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.