Evidence map›Paper›PMID 24585508›Full record

Observational studyCatheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions2014

The efficacy of "hybrid" percutaneous coronary intervention in chronic total occlusions caused by in-stent restenosis: insights from a US multicenter registry.

Georgios Christopoulos, Dimitri Karmpaliotis, Khaldoon Alaswad, William L Lombardi, J Aaron Grantham, Bavana V Rangan, Anna P Kotsia, Nicholas Lembo, David E Kandzari, James Lee and 6 more

Registry-linked trialOpen access · greenAbstract readComparative StudyMulticenter StudyObservational Study
In one paragraph

Observational study in Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02061436 (Multicenter Registry of Chronic Total Occlusion Interventions), which is not on this map. Cited by 32 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 1 pooled it
12.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02061436 recruitingnot on this map

Multicenter Registry of Chronic Total Occlusion Interventions

Typeobservational_patient_registrySponsorMinneapolis Heart Institute FoundationRan2012 to 2030Enrolled2,000ConditionsCoronary Artery Disease
3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 1 synthesis or guideline pooled it, 97 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Management of in-stent restenosis.EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology · 2022
    Article
  10. Article
  11. Article
  12. Occlusion patterns, strategies and procedural outcomes of percutaneous coronary intervention for in-stent chronic total occlusion.EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology · 2021
    Article
  13. Review
  14. Article
  15. Observational
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors at 8 institutions in 1 country.

Georgios ChristopoulosVA North Texas Healthcare System and UT Southwestern Medical Center, Dallas, Texas.
Dimitri Karmpaliotis
Khaldoon Alaswad
William L Lombardi
J Aaron Grantham
Bavana V Rangan
Anna P Kotsia
Nicholas Lembo
David E Kandzari
James Lee
Anna Kalynych
Harold Carlson
Santiago Garcia
Subhash Banerjee
Craig A Thompson
Emmanouil S Brilakis
Columbia University · USThe University of Texas Southwestern Medical Center · USAppleton Public Library · USMinneapolis VA Health Care System · USMissouri Heart Center · USPeaceHealth St. Joseph Medical Center · USVA North Texas Health Care System · USYale University · US

Funding

NORTH AND CENTRAL TEXAS CTSA FOR PEDIATRIC RESEARCHUL1RR024982 · NCRR · UT SOUTHWESTERN MEDICAL CENTER · PI TOTO, ROBERT DANIEL · 2007 to 2011
$27.9M
UT Southwestern Center for Translational Medicine (UL1/KL2/TL1)UL1TR001105 · NCATS · UT SOUTHWESTERN MEDICAL CENTER · PI TOTO, ROBERT DANIEL · 2013 to 2017
$24.5M
TRAINING IN CARDIOVASCULAR RESEARCHT32HL007360 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI HILL, JOSEPH A · 1985 to 2012
$11.8M
NCATS NIH HHS UL1 TR001105NCRR NIH HHS UL1 RR024982NHLBI NIH HHS T32 HL007360
6 · The paper itself

Abstract

objectivesTo examine the success and complication rates in percutaneous coronary intervention (PCI) for chronic total occlusions (CTO) caused by in-stent restenosis (ISR).

backgroundPCI for in-stent total occlusive disease has traditionally been associated with low success rates. We sought to examine angiographic and procedural outcomes of patients who underwent CTO PCI due to ISR using the novel "hybrid" algorithm, and compare them with patients with de novo CTOs.

methodsWe examined 521 consecutive patients who underwent CTO PCI at five high-volume PCI centers in the United States using the "hybrid" approach. Clinical, angiographic, and procedural outcomes were compared between CTOs due to ISR and de novo CTOs.

resultsThe target CTO was due to ISR in 57 of 521 patients (10.9%). Compared to patients with de novo CTOs, those with CTO due to ISR had higher frequency of diabetes (56.1% vs. 39.6%, P = 0.02) and less calcification (5.3% vs. 16.2%, P <0.001), but longer occlusion length [38 (29-55) vs. 30 (20-51), P = 0.04]. Technical success in the ISR and de novo group was 89.4% and 92.5% (P = 0.43), respectively; procedural success was 86.0% and 90.3% (P = 0.31), respectively; and the incidence of major adverse cardiac events was 3.5% and 2.2% (P = 0.63), respectively.

conclusionsUse of the "hybrid" approach to CTO PCI was associated with similarly high procedural success and similarly low major complication rates in patients with de novo and ISR CTOs.

Indexed as

StentsAgedAlgorithmsChronic DiseaseCoronary AngiographyCoronary OcclusionCoronary RestenosisCritical PathwaysFemaleHospitals, High-VolumeHumansMaleMiddle AgedPercutaneous Coronary InterventionRegistriesRisk Factorschronic total occlusionin-stent restenosispercutaneous coronary intervention

Identifiers

PMID24585508
PMCPMC4148463
OpenAlexW1517449073

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.