ReviewJournal of magnetic resonance imaging : JMRI2014
Quantification of liver iron with MRI: state of the art and remaining challenges.
Review in Journal of magnetic resonance imaging : JMRI, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 151 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
151 citing papers in PubMed, 2 syntheses or guidelines pooled it, 278 citations in OpenAlex.
- Reproducibility of liver iron concentration measured by R2* method based on 1.5-T MRI: a meta-analysis.European radiology · 2025Pooled it
- Clinical practice guidelines on hemochromatosis: Asian Pacific Association for the Study of the Liver.Hepatology international · 2023Guideline
- Effect of basis choice on quantitative parameter estimation in accelerated subspace reconstructions.Magnetic resonance letters · 2026Article
- Fast, Robust T2-IVIM Quantitative MRI With Distortion and Motion-Corrected Multi-Echo EPI.Magnetic resonance in medicine · 2026Article
- Reproducibility of ROI methods and reliability of conventional versus chemical shift-encoded MRI for hepatic fat and iron quantification.Abdominal radiology (New York) · 2026Article
- Inflammatory and resolution stages of hepatic injury: imaging with USPIO-enhanced MRI in mice.European radiology experimental · 2026Article
- Validation of Intravoxel Incoherent Motion MRI Using Perfused Explanted Human Livers.Magnetic resonance in medicine · 2026Article
- Accelerated free-breathing volumetric liver proton density fat fraction (PDFF) andMagma (New York, N.Y.) · 2026Article
- Free-Breathing Hybrid Technique for Simultaneous Morphological and Quantitative Abdominal Imaging at 0.55 T.Investigative radiology · 2026Article
- Abdominal simultaneous 3D water TMagnetic resonance in medicine · 2026Article
- Feasibility of Predicting the Triglyceride/High-Density Lipoprotein Cholesterol Ratio using Spectral Imaging with a Multi-Material Decomposition Technique on Fast kVp-Switching Dual-Energy CTCurrent medical imaging · 2026Article
- Navigator motion-resolved MR fingerprinting using implicit neural representation: Feasibility for free-breathing three-dimensional whole-liver multiparametric mapping.Magnetic resonance in medicine · 2026Article
- Multi-Center, Multi-Vendor Validation of Simultaneous MRI-Based Proton Density Fat Fraction and R2* Mapping Using a Combined Proton Density Fat Fraction-R2* Phantom.Journal of magnetic resonance imaging : JMRI · 2025Article
- Validation of R2* magnetic resonance imaging for quantifying secondary iron overload in pediatric patients.Diagnostic and interventional radiology (Ankara, Turkey) · 2025Article
- Role of Transient Elastography in Pediatric Transfusion Dependent Thalassemia Patients from Lower Socioeconomic Strata and its Correlation with Serum Ferritin: A Cross-Sectional Study.Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion · 2025Article
- Compressed Sensing-Accelerated Free-Breathing Liver MRI at 7 T.NMR in biomedicine · 2025Article
- A clinical predictive score of high liver iron content in metabolic hyperferritinemia: a retrospective cohort pilot study.BMC gastroenterology · 2025Article
- Inflammatory bowel disease and hereditary hemochromatosis: A case series.JPGN reports · 2025Article
- 5D image reconstruction exploiting space-motion-echo sparsity for accelerated free-breathing quantitative liver MRI.Medical image analysis · 2025Article
- Rapid liver tissue characterization using simultaneous multi-relaxation-time imaging: a comparative study with conventional magnetic resonance imaging.Quantitative imaging in medicine and surgery · 2025Article
91 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Liver iron overload is the histological hallmark of hereditary hemochromatosis and transfusional hemosiderosis, and can also occur in chronic hepatopathies. Iron overload can result in liver damage, with the eventual development of cirrhosis, liver failure, and hepatocellular carcinoma. Assessment of liver iron levels is necessary for detection and quantitative staging of iron overload and monitoring of iron-reducing treatments. This article discusses the need for noninvasive assessment of liver iron and reviews qualitative and quantitative methods with a particular emphasis on magnetic resonance imaging (MRI). Specific MRI methods for liver iron quantification include signal intensity ratio as well as R2 and R2* relaxometry techniques. Methods that are in clinical use, as well as their limitations, are described. Remaining challenges, unsolved problems, and emerging techniques to provide improved characterization of liver iron deposition are discussed.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.