Evidence map›Paper›PMID 24585398›Full record

ArticleMaternal and child health journal2014

Household food insecurity, maternal nutritional status, and infant feeding practices among HIV-infected Ugandan women receiving combination antiretroviral therapy.

Sera L Young, Albert H J Plenty, Flavia A Luwedde, Barnabas K Natamba, Paul Natureeba, Jane Achan, Julia Mwesigwa, Theodore D Ruel, Veronica Ades, Beth Osterbauer and 6 more

Registry-linked trialOpen access · greenAbstract read
In one paragraph

Article in Maternal and child health journal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00993031 (Protease Inhibitors to Reduce Malaria Morbidity in HIV-Infected Pregnant Women), which is not on this map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00993031 phase3completednot on this map

Protease Inhibitors to Reduce Malaria Morbidity in HIV-Infected Pregnant Women

TypeinterventionalSponsorUniversity of California, San FranciscoRan2009 to 2013Enrolled389ConditionsMalaria, HIV InfectionsArmsLopinavir/ritonavir, Efavirenz, Zidovudine, Lamivudine
3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.

  1. Pooled it
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  6. Infant and Young Child Feeding in the Context of HIV:medRxiv : the preprint server for health sciences · 2023
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  12. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 6 institutions in 2 countries.

Sera L YoungDivision of Nutritional Sciences, Cornell University, Ithaca, NY, USA, sera.young@cornell.edu.
Albert H J Plenty
Flavia A Luwedde
Barnabas K Natamba
Paul Natureeba
Jane Achan
Julia Mwesigwa
Theodore D Ruel
Veronica Ades
Beth Osterbauer
Tamara D Clark
Grant Dorsey
Edwin D Charlebois
Moses Kamya
Diane V Havlir
Deborah L Cohan
University of California, San Francisco · USCornell University · USMakerere University · UGMUJHU Research Collaboration · UGSan Francisco AIDS Foundation · USNYU Langone Health · US

Funding

San Francisco Vaccine and Prevention UnitUM1AI069496 · NIAID · PUBLIC HEALTH FOUNDATION ENTERPRISES · PI Susan Buchbinder, Diane V Havlir · 2012 to 2026
$30.5M
The immunologic consequences of prenatal exposure to malariaP01HD059454 · NICHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HAVLIR, DIANE V · 2008 to 2017
$22.6M
Health Consequences of Food & Nutrition Insecurity for HIV+ Women & Their InfantsK01MH098902 · NIMH · NORTHWESTERN UNIVERSITY · PI YOUNG, SERA LEWISE · 2012 to 2016
$854k
HIV Disease Progression in African ChildrenK23HD060459 · NICHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI RUEL, THEODORE DUMONT · 2010 to 2014
$627k
NIAID NIH HHS UM1 AI069496NICHD NIH HHS K23 HD060459NICHD NIH HHS P01 HD059454NIMH NIH HHS K01 MH098902PEPFAR
6 · The paper itself

Abstract

Household food insecurity (HHFI) may be a barrier to both optimal maternal nutritional status and infant feeding practices, but few studies have tested this relationship quantitatively, and never among HIV-infected individuals. We therefore described the prevalence of HHFI and explored if it was associated with poorer maternal nutritional status, shorter duration of exclusive breastfeeding (EBF) and fewer animal-source complementary foods. We assessed these outcomes using bivariate and multivariate analyses among 178 HIV-infected pregnant and breastfeeding (BF) women receiving combination antiretroviral therapy in the PROMOTE trial (NCT00993031), a prospective, longitudinal cohort study in Tororo, Uganda. HHFI was common; the prevalence of severe, moderate, and little to no household hunger was 7.3, 39.9, and 52.8 %, respectively. Poor maternal nutritional status was common and women in households experiencing moderate to severe household hunger (MSHH) had statistically significantly lower body mass index (BMIs) at enrollment (21.3 vs. 22.5, p < 0.01) and prior to delivery (22.6 vs. 23.8, p < 0.01). BMI across time during pregnancy, but not gestational weight gain, was significantly lower for MSHH [adjusted beta (95 % CI) -0.79 (-1.56, -0.02), p = 0.04; -2.06 (-4.31, 0.19), p = 0.07], respectively. The prevalence (95 % CI) of EBF at 6 months was 67.2 % (59.7-73.5 %), and the proportion of women BF at 12 months was 80.4 % (73.3-85.7 %). MSHH was not associated with prevalence of EBF at 6 months or BF at 12 months. However, among those women still EBF at 4 months (81.4 % of population), those experiencing MSHH were significantly more likely to cease EBF between 4 and 6 months (aHR 2.38, 95 % CI 1.02-5.58). The prevalence of HHFI, maternal malnutrition, and suboptimal infant feeding practices are high and the causal relationships among these phenomena must be further explored.

Indexed as

Maternal Nutritional Physiological PhenomenaNutritional StatusPregnancy Complications, InfectiousAdultAnalysis of VarianceAnti-HIV AgentsBody Mass IndexBreast FeedingChi-Square DistributionDepressionDrug Therapy, CombinationFamily CharacteristicsFemaleFood SupplyHIV InfectionsHumansAnti-HIV Agents

Identifiers

PMID24585398
PMCPMC4419705
OpenAlexW2090579913

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.