Observational studyAmerican journal of critical care : an official publication, American Association of Critical-Care Nurses2014
Patient predictors of dexmedetomidine effectiveness for sedation in intensive care units.
Observational study in American journal of critical care : an official publication, American Association of Critical-Care Nurses, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 22 citations in OpenAlex.
- Comparison of three sedation regimens for drug-induced sleep endoscopy.Sleep & breathing = Schlaf & Atmung · 2015Trial
- Standard- versus High-Dose Dexmedetomidine for Sedation in the Intensive Care Unit.Hospital pharmacy · 2022Article
- CYP2A6 and GABRA2 Gene Polymorphisms are Associated With Dexmedetomidine Drug Response.Frontiers in pharmacology · 2022Article
- Effects of Dexmedetomidine on the Pharmacokinetics of Parecoxib and Its Metabolite Valdecoxib in Beagles by UPLC-MS/MS.BioMed research international · 2020Article
- Recovery time after oral and maxillofacial ambulatory surgery with dexmedetomidine: an observational study.Clinical oral investigations · 2019Observational
- Clinical Pharmacokinetics and Pharmacodynamics of Dexmedetomidine.Clinical pharmacokinetics · 2017Review
- Interpatient variability in dexmedetomidine response: a survey of the literature.TheScientificWorldJournal · 2014Review
- The effect of alpha-2A adrenergic receptor (ADRA2A) genetic polymorphisms on the depth of sedation of dexmedetomidine: a genetic observational pilot study.Brazilian journal of anesthesiology (Elsevier)Observational
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
backgroundDexmedetomidine, a selective α2-adrenergic receptor agonist, is increasingly used as a sedative in intensive care despite variations in patients' responses.
objectivesTo determine the effectiveness of dexmedetomidine as a sedative and specific patient characteristics that play a role in adequate sedation with dexmedetomidine.
methodsA 6-month, pilot, prospective observational study was performed in a medical intensive care unit at an academic medical center. Patients receiving dexmedetomidine were followed up until use of the drug was stopped and they were classified as nonresponders or responders. Effective sedation was defined as a score of 3 to 4 on the Sedation Agitation Scale after the administration of dexmedetomidine. Patient characteristics, laboratory values, home and inpatient medications, and dexmedetomidine dosing information were collected to identify predictors of clinical response.
resultsDuring the 6-month study period, 38 patients received dexmedetomidine. The drug was ineffective as a sedative in 19 patients (50%) and effective in 11 (29%). Effectiveness could not be assessed in 8 patients because of clinical confounders. According to standard multiple logistic regression analysis, successful sedation was more likely in patients with a lower score on the Acute Physiology and Chronic Health Evaluation II (Odds Ratio [OR] 0.81; 95% CI, -0.39 to -0.03) and patients who took antidepressants at home (OR 10.27; 95% CI, 0.23 to 4.43) than in patients who had a higher score or did not take antidepressants at home.
conclusionsEffective sedation with dexmedetomidine is variable.
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