ArticleJournal of virology1988
Human immunodeficiency virus infection of monoblastoid cells: cellular differentiation determines the pattern of virus replication.
Article in Journal of virology, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Glucocorticoid treatment at moderate doses of SIVmac251-infected rhesus macaques decreases the frequency of circulating CD14+CD16++ monocytes but does not alter the tissue virus reservoir.AIDS research and human retroviruses · 2015Article
- Monocyte heterogeneity underlying phenotypic changes in monocytes according to SIV disease stage.Journal of leukocyte biology · 2010Article
- Activation of human monocytes after infection by human coronavirus 229E.Virus research · 2007Article
- 1,25-Dihydroxyvitamin D3 upregulates functional CXCR4 human immunodeficiency virus type 1 coreceptors in U937 minus clones: NF-kappaB-independent enhancement of viral replication.Journal of virology · 1998Article
- Chronic human immunodeficiency virus type 1 infection of myeloid cells disrupts the autoregulatory control of the NF-kappaB/Rel pathway via enhanced IkappaBalpha degradation.Journal of virology · 1996Article
- Equine infectious anemia virus replication is upregulated during differentiation of blood monocytes from acutely infected horses.Journal of virology · 1996Article
- Regulation of human immunodeficiency virus type 1 and cytokine gene expression in myeloid cells by NF-kappa B/Rel transcription factors.Microbiological reviews · 1995Review
- The immunopathogenesis of equine infectious anemia virus.Virus research · 1994Review
- Transcription of human c-myc in permeabilized nuclei is associated with formation of Z-DNA in three discrete regions of the gene.The EMBO journal · 1992Article
- Wild-type equine infectious anemia virus replicates in vivo predominantly in tissue macrophages, not in peripheral blood monocytes.Journal of virology · 1992Article
- Differential susceptibilities of U-937 cell clones to infection by human immunodeficiency virus type 1.Journal of virology · 1992Article
- Negative regulation of human immunodeficiency virus type 1 expression in monocytes: role of the 65-kDa plus 50-kDa NF-kappa B dimer.Proceedings of the National Academy of Sciences of the United States of America · 1991Article
- Replication of an acutely lethal simian immunodeficiency virus activates and induces proliferation of lymphocytes.Journal of virology · 1991Article
- Human immunodeficiency virus induction of malignant transformation in human B lymphocytes.Proceedings of the National Academy of Sciences of the United States of America · 1991Article
- Enhancement of human immunodeficiency virus 1 replication in monocytes by 1,25-dihydroxycholecalciferol.Proceedings of the National Academy of Sciences of the United States of America · 1991Article
- Proviral sequences detected by polymerase chain reaction in peripheral blood cells of horses with equine infectious anemia lentivirus.Archives of virology · 1991Article
- Coordinate enhancement of cytokine gene expression in human immunodeficiency virus type 1-infected promonocytic cells.Journal of virology · 1990Article
- Increased human immunodeficiency virus (HIV) expression in chronically infected U937 cells upon in vitro differentiation by hydroxyvitamin D3: roles of interferon and tumor necrosis factor in regulation of HIV production.Journal of virology · 1990Article
- Reinfection results in accumulation of unintegrated viral DNA in cytopathic and persistent human immunodeficiency virus type 1 infection of CEM cells.The Journal of experimental medicine · 1990Article
- Infection of the human monocytic cell line Mono Mac6 with human immunodeficiency virus types 1 and 2 results in long-term production of virus variants with increased cytopathogenicity for CD4+ T cells.Journal of virology · 1990Article
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3 authors.
Funding
Abstract
Stringent control of human immunodeficiency virus (HIV) replication was observed in the human monoblastoid cell line U937. A low-multiplicity infection of these cells by the LAV1 strain of HIV was productive for 2.5 days; then virus replication became restricted and no further evidence of virion production was observed. The dramatic decrease in HIV production was due in part of reduced accumulation of cytoplasmic viral RNA and occurred in the absence of evident cytopathic effects. In contrast, infected cells induced to differentiate by phorbol ester, vitamin D3, or lymphokine supernatant did not release markers of HIV despite the accumulation of significant levels of cytoplasmic viral RNA. HIV infection altered the pattern of c-myc RNA accumulation in U937 cells. Expression of this gene changes normally in response to the state of cellular differentiation; in infected cells the level of c-myc expression was correlated to the levels of viral RNA accumulation and not to cellular differentiation. These results suggest that restricted replication of HIV in monocytes might be an important mechanism of virus persistence and demonstrate a relationship between HIV replication and monocyte differentiation.
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