ArticleJournal of molecular evolution1988
Concerted gene duplications in the two keratin gene families.
Article in Journal of molecular evolution, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 53 citations in OpenAlex.
- Externalized Keratin 8: A Target at the Interface of Microenvironment and Intracellular Signaling in Colorectal Cancer Cells.Cancers · 2018Article
- Dynamic evolution of the alpha (α) and beta (β) keratins has accompanied integument diversification and the adaptation of birds into novel lifestyles.BMC evolutionary biology · 2014Article
- Identification of reptilian genes encoding hair keratin-like proteins suggests a new scenario for the evolutionary origin of hair.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- The human keratins: biology and pathology.Histochemistry and cell biology · 2008Review
- Overcoming functional redundancy to elicit pachyonychia congenita-like nail lesions in transgenic mice.Molecular and cellular biology · 2005Article
- Regulation of keratin and integrin gene expression in cancer and drug resistance.Cytotechnology · 1998Article
- Oncogenic regulation and function of keratins 8 and 18.Cancer metastasis reviews · 1996Review
- cis regulation of the keratin 18 gene in transgenic mice.Molecular and cellular biology · 1993Article
- A single human keratin 18 gene is expressed in diverse epithelial cells of transgenic mice.The Journal of cell biology · 1990Article
- Allele frequencies and segregation of human polymorphic keratins K4 and K5.American journal of human genetics · 1990Article
- Embryonic expression of the human 40-kD keratin: evidence from a processed pseudogene sequence.American journal of human genetics · 1988Article
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Evolutionary trees were derived from the keratin protein sequences using the Phylogeny Analysis Using Parsimony (PAUP) set of programs. Three major unexpected conclusions were derived from the analysis: The smallest keratin protein subunit, K#19 (Moll et al. 1982), is not the most primitive one, but has evolved to fulfill a highly specialized function, presumably to redress the unbalanced synthesis of keratin subunits. Second, the ancestors of keratins expressed in the early embryonic stages, K#8 and K#18, were the first to diverge from the ancestors of all the other keratins. The branches leading to these two keratins are relatively short, indicating a comparatively strong selection against changes in the sequences of these two proteins. Third, the two keratin families show extraordinary parallelism in their patterns of gene duplications. In both families the genes expressed in embryos diverged first, later bursts of gene duplications created the subfamilies expressed in various differentiated cells, and relatively recent gene duplications gave rise to the hair keratin genes and separated the basal cell-specific keratin from those expressed under hyperproliferative conditions. The parallelism of gene duplications in the two keratin gene families implies a mechanism in which duplications in one family influence duplication events in the other family.
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