ArticleApplied microbiology and biotechnology2014
Improved n-butanol production by a non-acetone producing Clostridium pasteurianum DSMZ 525 in mixed substrate fermentation.
Article in Applied microbiology and biotechnology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 73 citations in OpenAlex.
- Metabolic Flux and Growth Profiling of Megasphaera cerevisiae for Medium-Chain Fatty Acid Synthesis.Environmental microbiology reports · 2026Article
- Control of redox potential in a novel continuous bioelectrochemical system led to remarkable metabolic and energetic responses of Clostridium pasteurianum grown on glycerol.Microbial cell factories · 2022Article
- Enhanced Biosynthesis ofApplied biochemistry and biotechnology · 2022Article
- Phenotype analysis of cultivation processes via unsupervised machine learning: Demonstration forEngineering in life sciences · 2022Article
- Microbial detoxification of lignocellulosic biomass hydrolysates: Biochemical and molecular aspects, challenges, exploits and future perspectives.Frontiers in bioengineering and biotechnology · 2022Review
- Effect of Endogenous and Exogenous Butyric Acid on Butanol Production From CO by EnrichedFrontiers in bioengineering and biotechnology · 2022Article
- Metabolomic and kinetic investigations on the electricity-aided production of butanol byEngineering in life sciences · 2021Article
- Orange Bagasse Pellets as a Carbon Source for Biobutanol Production.Current microbiology · 2020Article
- Increased Butanol Yields through Cosubstrate Fermentation of Jerusalem Artichoke Tubers and Crude Glycerol byACS omega · 2019Article
- Improved electrocompetence and metabolic engineering ofEngineering in life sciences · 2019Article
- ImprovedApplied and environmental microbiology · 2019Article
- Metabolic engineering ofBiotechnology for biofuels · 2019Article
- Exploitation of novel wild type solventogenic strains for butanol production.Biotechnology for biofuels · 2018Review
- Metabolic and proteomic analyses of product selectivity and redox regulation in Clostridium pasteurianum grown on glycerol under varied iron availability.Microbial cell factories · 2017Article
- Towards improved butanol production through targeted genetic modification of Clostridium pasteurianum.Metabolic engineering · 2017Article
- Germinants and Their Receptors in Clostridia.Journal of bacteriology · 2016Review
- Fermentation of mixed substrates by Clostridium pasteurianum and its physiological, metabolic and proteomic characterizations.Microbial cell factories · 2016Article
- Consolidating biofuel platforms through the fermentative bioconversion of crude glycerol to butanol.World journal of microbiology & biotechnology · 2016Review
- Bioconversion technologies of crude glycerol to value added industrial products.Biotechnology reports (Amsterdam, Netherlands) · 2016Review
- Effective isopropanol-butanol (IB) fermentation with high butanol content using a newly isolatedBiotechnology for biofuels · 2016Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The kinetics of growth, acid and solvent production in batch culture of Clostridium pasteurianum DSMZ 525 were examined in mixed or mono-substrate fermentations. In pH-uncontrolled batch cultures, the addition of butyric acid or glucose significantly enhanced n-butanol production and the ratio of butanol/1,3-propanediol. In pH-controlled batch culture at pH = 6, butyric acid addition had a negative effect on growth and did not lead to a higher n-butanol productivity. On the other hand, mixed substrate fermentation using glucose and glycerol enhanced the growth and acid production significantly. Glucose limitation in the mixed substrate fermentation led to the reduction or inhibition of the glycerol consumption by the growing bacteria. Therefore, for the optimal growth and n-butanol production by C. pasteurianum, a limitation of either substrate should be avoided. Under optimized batch conditions, n-butanol concentration and maximum productivity achieved were 21 g/L, and 0.96 g/L × h, respectively. In comparison, mixed substrate fermentation using biomass hydrolysate and glycerol gave a n-butanol concentration of 17 g/L with a maximum productivity of 1.1 g/L × h. In terms of productivity and final n-butanol concentration, the results demonstrated that C. pasteurianum DSMZ 525 is well suitable for n-butanol production from mixed substrates of biomass hydrolysate and glycerol and represents an alternative promising production strain.
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