ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2014
Incubation of methamphetamine and palatable food craving after punishment-induced abstinence.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 90 papers.
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Who cites it
90 citing papers in PubMed, 121 citations in OpenAlex.
- Frequency of Consuming Foods Predicts Changes in Cravings for Those Foods During Weight Loss: The POUNDS Lost Study.Obesity (Silver Spring, Md.) · 2017Trial
- Robust effects of food deprivation as a relapse trigger: comparison to other stressors, and investigation of predictive individual traits in male and female rats.Psychopharmacology · 2026Article
- Systemic Everolimus Does Not Block the Incubation of Methamphetamine-Craving: A Dose-Response Study.Addiction biology · 2026Article
- Escalated Oxycodone Self-Administration Is Associated with Activation of Specific Gene Networks in the Rat Dorsal Striatum.International journal of molecular sciences · 2025Article
- A simple action reduces high-fat diet intake and obesity in mice.Current biology : CB · 2025Article
- A neurally constrained computational model of context-dependent fear extinction recall and relapse.Communications biology · 2025Article
- Characterization of serum and brain cytokine levels following prolonged binge-like methamphetamine self-administration and cued methamphetamine seeking.Journal of neuroimmunology · 2025Article
- Neurobiology of the incubation of drug craving: An update.Pharmacological reviews · 2025Review
- Remission from addiction: erasing the wrong circuits or making new ones?Nature reviews. Neuroscience · 2025Review
- Glutamate concentration of medial prefrontal cortex is inversely associated with addictive behaviors: a translational study.Translational psychiatry · 2024Article
- Connecting self-report and instrumental behavior during incubation of food craving in humans.Learning & memory (Cold Spring Harbor, N.Y.) · 2024Article
- Activation of CGRP neurons in the parabrachial nucleus suppresses addictive behavior.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Relapse after electric barrier-induced voluntary abstinence: A review.Current opinion in neurobiology · 2024Review
- Delay of punishment highlights differential vulnerability to developing addiction-like behavior toward sweet food.Translational psychiatry · 2024Article
- Modeling methamphetamine use disorder and relapse in animals: short- and long-term epigenetic, transcriptional., and biochemical consequences in the rat brain.Neuroscience and biobehavioral reviews · 2023Review
- A comparison of renewal, spontaneous recovery, and reacquisition after punishment and extinction.Learning & behavior · 2023Article
- Preventing incubation of drug craving to treat drug relapse: from bench to bedside.Molecular psychiatry · 2023Review
- Learning to stop responding.Behavioural processes · 2023Review
- Acute food deprivation-induced relapse to heroin seeking after short and long punishment-imposed abstinence in male rats.Psychopharmacology · 2023Article
- Environmental enrichment facilitates electric barrier induced heroin abstinence after incubation of craving in male and female rats.Drug and alcohol dependence · 2023Article
30 more citing papers are in PubMed but not listed here.
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
In a rat model of drug craving and relapse, cue-induced drug seeking progressively increases after withdrawal from methamphetamine and other drugs, a phenomenon termed 'incubation of drug craving'. However, current experimental procedures used to study incubation of drug craving do not incorporate negative consequences of drug use, which is a common factor promoting abstinence in humans. Here, we studied whether incubation of methamphetamine craving is observed after suppression of drug seeking by adverse consequences (punishment). We trained rats to self-administer methamphetamine or palatable food for 9 h per day for 14 days; reward delivery was paired with a tone-light cue. Subsequently, for one group within each reward type, 50% of the lever-presses were punished by mild footshock for 9-10 days, whereas for the other group lever-presses were not punished. Shock intensity was gradually increased over time. Next, we assessed cue-induced reward seeking in 1-h extinction sessions on withdrawal days 2 and 21. Response-contingent punishment suppressed extended-access methamphetamine or food self-administration; surprisingly, food-trained rats showed greater resistance to punishment than methamphetamine-trained rats. During the relapse tests, both punished and unpunished methamphetamine- and food-trained rats showed significantly higher cue-induced reward seeking on withdrawal day 21 than on day 2. These results demonstrate that incubation of both methamphetamine and food craving occur after punishment-induced suppression of methamphetamine or palatable food self-administration. Our procedure can be used to investigate mechanisms of relapse to drug and palatable food seeking under conditions that more closely approximate the human condition.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.