ArticleApplied and environmental microbiology2014
The iron stimulon and fur regulon of Geobacter sulfurreducens and their role in energy metabolism.
Article in Applied and environmental microbiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 36 citations in OpenAlex.
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- Multi-heme cytochrome-mediated extracellular electron transfer by the anaerobic methanotroph 'Candidatus Methanoperedens nitroreducens'.Nature communications · 2023Article
- Global transcriptional analysis of Geobacter sulfurreducens gsu1771 mutant biofilm grown on two different support structures.PloS one · 2023Article
- Metabolic turnover of cysteine-related thiol compounds at environmentally relevant concentrations byFrontiers in microbiology · 2022Article
- Reduction Kinetic of Water Soluble Metal Salts byFrontiers in microbiology · 2022Article
- The bacterial iron sensor IdeR recognizes its DNA targets by indirect readout.Nucleic acids research · 2021Article
- Bacterial iron detoxification at the molecular level.The Journal of biological chemistry · 2020Review
- Cobalt Resistance via Detoxification and Mineralization in the Iron-Reducing BacteriumFrontiers in microbiology · 2020Article
- IdeR, a DtxR Family Iron Response Regulator, Controls Iron Homeostasis, Morphological Differentiation, Secondary Metabolism, and the Oxidative Stress Response in Streptomyces avermitilis.Applied and environmental microbiology · 2018Article
- Article
- The Role of Fur in the Transcriptional and Iron Homeostatic Response ofFrontiers in microbiology · 2018Article
- Genetic switches and related tools for controlling gene expression and electrical outputs of Geobacter sulfurreducens.Journal of industrial microbiology & biotechnology · 2016Article
- K-shell Analysis Reveals Distinct Functional Parts in an Electron Transfer Network and Its Implications for Extracellular Electron Transfer.Frontiers in microbiology · 2016Article
- Deciphering Fur transcriptional regulatory network highlights its complex role beyond iron metabolism in Escherichia coli.Nature communications · 2014Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Iron plays a critical role in the physiology of Geobacter species. It serves as both an essential component for proteins and cofactors and an electron acceptor during anaerobic respiration. Here, we investigated the iron stimulon and ferric uptake regulator (Fur) regulon of Geobacter sulfurreducens to examine the coordination between uptake of Fe(II) and the reduction of Fe(III) at the transcriptional level. Gene expression studies across a variety of different iron concentrations in both the wild type and a Δfur mutant strain were used to determine the iron stimulon. The stimulon consists of a broad range of gene products, ranging from iron-utilizing to central metabolism and iron reduction proteins. Integration of gene expression and chromatin immunoprecipitation (ChIP) data sets assisted in the identification of the Fur transcriptional regulatory network and Fur's role as a regulator of the iron stimulon. Additional physiological and transcriptional analyses of G. sulfurreducens grown with various Fe(II) concentrations revealed the depth of Fur's involvement in energy metabolism and the existence of redundancy within the iron-regulatory network represented by IdeR, an alternative iron transcriptional regulator. These characteristics enable G. sulfurreducens to thrive in environments with fluctuating iron concentrations by providing it with a robust mechanism to maintain tight and deliberate control over intracellular iron homeostasis.
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