Evidence map›Paper›PMID 24584136›Full record

ArticleNeurosurgery2014

Use of cone-beam computed tomography angiography in planning for gamma knife radiosurgery for arteriovenous malformations: a case series and early report.

Mina G Safain, Jason P Rahal, Ami Raval, Mark J Rivard, John E Mignano, Julian K Wu, Adel M Malek

Abstract read
In one paragraph

Article in Neurosurgery, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Article
  3. Optimizing contrast-enhanced cone-beam CT protocol to facilitate simultaneous visualization of neurovascular pathologies and surrounding structures of interest.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2019
    Article
  4. Integrating 3D Rotational Angiography into Gamma Knife Planning.AJNR. American journal of neuroradiology · 2018
    Article
  5. Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Mina G Safain*Cerebrovascular and Endovascular Division, Department of Neurosurgery, ‡Department of Radiation Oncology, Tufts Medical Center and Tufts University School of Medicine, Boston, Massachusetts; §Boston Gamma Knife Center, Boston, Massachusetts.
Jason P Rahal
Ami Raval
Mark J Rivard
John E Mignano
Julian K Wu
Adel M Malek
Tufts University · USTufts Medical Center · US

Funding

Flow 3D+T Image Reconstruction Algorithms for Enhanced Cerebral AngiographyR21HL102685 · NHLBI · CHARLES STARK DRAPER LABORATORY · PI MANGOUBI, RAMI · 2010 to 2011
$373k
NHLBI NIH HHS R21 HL102685NHLBI NIH HHS R21HL102685
6 · The paper itself

Abstract

backgroundThe effectiveness of Gamma Knife radiosurgery (GKR) for cerebral arteriovenous malformations (AVMs) is predicated on inclusion of the entire nidus while excluding normal tissue. As such, GKR may be limited by the resolution and accuracy of the imaging modality used in targeting.

objectiveWe present the first case series to demonstrate the feasibility of using ultrahigh-resolution C-arm cone-beam computed tomography angiography (CBCT-A) in AVM targeting.

methodsFrom June 2009 to June 2013, CBCT-A was used for targeting of all patients with AVMs treated with GKR at our institution. Patients underwent Leksell stereotactic head frame placement followed by catheter-based biplane 2-dimensional digital subtraction angiography, 3-dimensional rotational angiography, as well as CBCT-A. The CBCT-A dataset was used for stereotactic planning for GKR. Patients were followed at 1, 3, 6, and 12 months and then annually thereafter.

resultsCBCT-A-based targeting was used in 22 consecutive patients. CBCT-A provided detailed spatial resolution and sensitivity of nidal angioarchitecture enabling treatment. The average radiation dose to the margin of the AVM nidus corresponding to the 50% isodose line was 15.6 Gy. No patient had treatment-associated hemorrhage. At early follow-up (mean, 16 months), 84% of patients had a decreasing or obliterated AVM nidus.

conclusionCBCT-A-guided radiosurgery is feasible and useful because it provides sufficient detailed resolution and sensitivity for imaging brain AVMs.

Indexed as

Cerebral AngiographyCone-Beam Computed TomographyRadiosurgeryAdultArteriovenous FistulaFemaleHumansImaging, Three-DimensionalIntracranial Arteriovenous MalformationsMaleMiddle AgedRadiation DosageTreatment Outcome

Identifiers

PMID24584136
PMCPMC4028381
OpenAlexW2029842012

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.