ArticleCirculation journal : official journal of the Japanese Circulation Society2014
Intracellular calcium and the mechanism of the dip in the anodal strength-interval curve in cardiac tissue.
Article in Circulation journal : official journal of the Japanese Circulation Society, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 7 citations in OpenAlex.
- Bidomain modeling of electrical and mechanical properties of cardiac tissue.Biophysics reviews · 2021Review
- Modeling bipolar stimulation of cardiac tissue.Chaos (Woodbury, N.Y.) · 2017Article
- Cardiac strength-interval curves calculated using a bidomain tissue with a parsimonious ionic current.PloS one · 2017Article
- Bidomain Predictions of Virtual Electrode-Induced Make and Break Excitations around Blood Vessels.Frontiers in bioengineering and biotechnology · 2017Article
- The Mechanism of Reflection Type Reentry: A Simulation Study.Journal of cardiovascular electrophysiology · 2015Article
- ELECTRICAL INSTABILITY DUE TO REGIONAL INCREASE IN EXTRACELLULAR POTASSIUM ION CONCENTRATION.Journal of nature and science · 2015Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThe strength-interval (SI) curve is an important measure of refractoriness in cardiac tissue. The anodal SI curve contains a "dip" in which the S2 threshold increases with interval. Two explanations exist for this dip: (1) electrotonic interaction between regions of depolarization and hyperpolarization; and (2) the sodium-calcium exchange (NCX) current. The goal of this study is to use mathematical modeling to determine which explanation is correct. METHODS AND
resultsThe bidomain model represents cardiac tissue and the Luo-Rudy model describes the active membrane. The SI curve is determined by applying a threshold stimulus at different time intervals after a previous action potential. During space-clamped and equal-anisotropy-ratios simulations, anodal excitation does not occur. During unequal-anisotropy-ratios simulations, electrotonic currents, not membrane currents, are present during the few milliseconds before excitation. The dip disappears with no NCX current, but is present with 50% or 75% reduction of it. The calcium-induced-calcium-release (CICR) current has little effect on the dip.
conclusionsThese results indicate that neither the NCX nor the CICR current is responsible for the dip in the anodal SI curve. It is caused by the electrotonic interaction between regions of depolarization and hyperpolarization following the S2 stimulus.
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