ArticleSchizophrenia bulletin2015
Alterations in brain activation during cognitive empathy are related to social functioning in schizophrenia.
Article in Schizophrenia bulletin, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 4 of them syntheses that pooled it.
What it found
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The trial behind it
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Who cites it
25 citing papers in PubMed, 4 syntheses or guidelines pooled it, 53 citations in OpenAlex.
- Adjunctive transcranial direct current stimulation for cognitive improvement in schizophrenia: insights from a systematic review and exploratory meta-analysis.Frontiers in psychiatry · 2025Pooled it
- The social cognitive and neural mechanisms that underlie social functioning in individuals with schizophrenia - a review.Translational psychiatry · 2023Pooled it
- Social functioning and brain imaging in individuals at clinical high-risk for psychosis: A systematic review.Schizophrenia research · 2021Pooled it
- A Systematic and Meta-analytic Review of Neural Correlates of Functional Outcome in Schizophrenia.Schizophrenia bulletin · 2017Pooled it
- Individuals with High Social Anhedonia but not Schizophrenia Exhibited Altered Empathy in Daily Life.Schizophrenia bulletin · 2026Article
- No Sex-based Differences in Self-reported Empathy between Patients with Schizophrenia and Control Subjects.Actas espanolas de psiquiatria · 2024Article
- Cognitive Empathy and Longitudinal Changes in Temporo-Parietal Junction Thickness in Schizophrenia.Frontiers in psychiatry · 2021Article
- Effect of Risperidone Monotherapy on Dynamic Functional Connectivity of Insular Subdivisions in Treatment-Naive, First-Episode Schizophrenia.Schizophrenia bulletin · 2020Article
- Nonsocial and social cognition in schizophrenia: current evidence and future directions.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2019Article
- Spontaneous low-frequency fluctuations in the neural system for emotional perception in major psychiatric disorders: amplitude similarities and differences across frequency bandsJournal of psychiatry & neuroscience : JPN · 2019Article
- Change in Objective Measure of Empathic Accuracy Following Social Cognitive Training.Frontiers in psychiatry · 2019Article
- How Music Impacts Visual Attention Training in Schizophrenia: A Pilot Study.The Journal of nervous and mental disease · 2018Article
- The Effect of High-Definition Transcranial Direct Current Stimulation of the Right Inferior Frontal Gyrus on Empathy in Healthy Individuals.Frontiers in human neuroscience · 2018Article
- Using Cognitive Neuroscience to Improve Mental Health Treatment: A Comprehensive Review.Journal of the Society for Social Work and Research · 2018Article
- Neural correlates of preserved facial affect perception in high functioning schizophrenia.Psychiatry research. Neuroimaging · 2017Article
- Functional MRI examination of empathy for pain in people with schizophrenia reveals abnormal activation related to cognitive perspective-taking but typical activation linked to affective sharing.Journal of psychiatry & neuroscience : JPN · 2017Article
- Default mode functional connectivity is associated with social functioning in schizophrenia.Journal of abnormal psychology · 2017Article
- Fronto-temporal connectivity predicts cognitive empathy deficits and experiential negative symptoms in schizophrenia.Human brain mapping · 2017Article
- The social brain network in 22q11.2 deletion syndrome: a diffusion tensor imaging study.Behavioral and brain functions : BBF · 2017Article
- Cortical thickness of neural substrates supporting cognitive empathy in individuals with schizophrenia.Schizophrenia research · 2017Article
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 2 countries.
Funding
Abstract
Impaired cognitive empathy (ie, understanding the emotional experiences of others) is associated with poor social functioning in schizophrenia. However, it is unclear whether the neural activity underlying cognitive empathy relates to social functioning. This study examined the neural activation supporting cognitive empathy performance and whether empathy-related activation during correctly performed trials was associated with self-reported cognitive empathy and measures of social functioning. Thirty schizophrenia outpatients and 24 controls completed a cognitive empathy paradigm during functional magnetic resonance imaging. Neural activity corresponding to correct judgments about the expected emotional expression in a social interaction was compared in schizophrenia subjects relative to control subjects. Participants also completed a self-report measure of empathy and 2 social functioning measures (social competence and social attainment). Schizophrenia subjects demonstrated significantly lower accuracy in task performance and were characterized by hypoactivation in empathy-related frontal, temporal, and parietal regions as well as hyperactivation in occipital regions compared with control subjects during accurate cognitive empathy trials. A cluster with peak activation in the supplementary motor area (SMA) extending to the anterior midcingulate cortex (aMCC) correlated with social competence and social attainment in schizophrenia subjects but not controls. These results suggest that neural correlates of cognitive empathy may be promising targets for interventions aiming to improve social functioning and that brain activation in the SMA/aMCC region could be used as a biomarker for monitoring treatment response.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.