ArticleInternational journal of environmental research and public health2014
Effects of moderate strength cold air exposure on blood pressure and biochemical indicators among cardiovascular and cerebrovascular patients.
Article in International journal of environmental research and public health, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 67 citations in OpenAlex.
- Sources of inaccuracy in the measurement of adult patients' resting blood pressure in clinical settings: a systematic review.Journal of hypertension · 2017Pooled it
- Efficacy of Continuous Suctioning in Adenoidectomy Haemostasis-Clinical Study.Medicina (Kaunas, Lithuania) · 2023Trial
- Ambient cold exposure and myocardial infarction risk in Tianjin, China: a distributed lag non-linear analysis.BMC public health · 2026Article
- Associations between extreme temperatures and hospitalizations among Chinese cancer patients with atrial fibrillation: a case-crossover study.Cardio-oncology (London, England) · 2026Article
- Extreme Weather Events, Air Pollution, and Cardiovascular Health: Mechanisms and Challenges.Reviews in cardiovascular medicine · 2026Review
- Seasonal variations in outcomes following spontaneous intracerebral hemorrhage: a case control study.BMC neurology · 2026Article
- Seasonal Variations in the Risk of Outpatient Acute Kidney Injury in Patients with Chronic Kidney Disease.Diagnostics (Basel, Switzerland) · 2026Article
- Meteorological factors modulate idiopathic epistaxis risk: a 12-year retrospective study in Changshu.Frontiers in public health · 2026Article
- Child Stunting and Temperature Anomalies: A Cross-Sectional Study in Burkina Faso and Kenya.Children (Basel, Switzerland) · 2025Article
- Angiotensin II participates in mitochondrial thermogenic functions via the activation of glycolysis in chemically induced human brown adipocytes.Scientific reports · 2024Article
- Molecular Challenges and Opportunities in Climate Change-Induced Kidney Diseases.Biomolecules · 2024Review
- The Impact of Climate Change and Extreme Weather Conditions on Cardiovascular Health and Acute Cardiovascular Diseases.Journal of clinical medicine · 2024Review
- The effect of forest-based health and wellness on the stress-relieve of middle-aged people.Frontiers in public health · 2024Article
- Temperature variability increases the onset risk of ischemic stroke: A 10-year study in Tianjin, China.Frontiers in neurology · 2023Article
- Seasonal variation in the detection rate and all-cause in-hospital mortality of AKI in China: A nationwide cohort study.Frontiers in public health · 2022Article
- Association between Physiological Equivalent Temperature (PET) with adverse pregnancy outcomes in Ahvaz, southwest of Iran.BMC pregnancy and childbirth · 2021Article
- The association of outdoor temperature with blood pressure, and its influence on future cardio-cerebrovascular disease risk in cold areas.Journal of hypertension · 2020Article
- Short-term effects of ambient air pollution and outdoor temperature on biomarkers of myocardial damage, inflammation and oxidative stress in healthy adults.Environmental epidemiology (Philadelphia, Pa.) · 2019Article
- Maternal high-fat diet programs cerebrovascular remodeling in adult rat offspring.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2018Article
- Impact of Cold Exposure on the Reproductive Function in Female Rats.BioMed research international · 2018Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The effects of cold air on cardiovascular and cerebrovascular diseases were investigated in an experimental study examining blood pressure and biochemical indicators. Zhangye, a city in Gansu Province, China, was selected as the experimental site. Health screening and blood tests were conducted, and finally, 30 cardiovascular disease patients and 40 healthy subjects were recruited. The experiment was performed during a cold event during 27-28 April 2013. Blood pressure, catecholamine, angiotensin II (ANG-II), cardiac troponin I (cTnI), muscle myoglobin (Mb) and endothefin-1 (ET-1) levels of the subjects were evaluated 1 day before, during the 2nd day of the cold exposure and 1 day after the cold air exposure. Our results suggest that cold air exposure increases blood pressure in cardiovascular disease patients and healthy subjects via the sympathetic nervous system (SNS) that is activated first and which augments ANG-II levels accelerating the release of the norepinephrine and stimulates the renin-angiotensin system (RAS). The combined effect of these factors leads to a rise in blood pressure. In addition, cold air exposure can cause significant metabolism and secretion of Mb, cTnI and ET-1 in subjects; taking the patient group as an example, ET-1 was 202.7 ng/L during the cold air exposure, increased 58 ng/L compared with before the cold air exposure, Mb and cTnI levels remained relatively high (2,219.5 ng/L and 613.2 ng/L, increased 642.1 ng/L and 306.5 ng/L compared with before the cold air exposure, respectively) 1-day after the cold exposure. This showed that cold air can cause damage to patients' heart cells, and the damage cannot be rapidly repaired. Some of the responses related to the biochemical markers indicated that cold exposure increased cardiovascular strain and possible myocardial injury.
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