Phosphodiesterases maintain signaling fidelity via compartmentalization of cyclic nucleotides.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

23 citing papers in PubMed.

1. Phosphodiesterase Type 5 Inhibitors in Male Reproduction: Molecular Mechanisms and Clinical Implications for Fertility Management.Cells · 2025
   Review
2. Role of Phosphodiesterases in Biology and Pathology 2.0.International journal of molecular sciences · 2024
   Article
3. Calcium and bicarbonate signaling pathways have pivotal, resonating roles in matching ATP production to demand.eLife · 2023
   Article
4. Phosphodiesterase 5a Signalling in Skeletal Muscle Pathophysiology.International journal of molecular sciences · 2022
   Article
5. Compartmentalized Signaling in Aging and Neurodegeneration.Cells · 2021
   Review
6. An update of cyclic nucleotide phosphodiesterase as a target for cardiac diseases.Expert opinion on drug discovery · 2021
   Review
7. The Role of Cyclic AMP Signaling in Cardiac Fibrosis.Cells · 2019
   Review
8. Compartmentalized cAMP Generation by Engineered Photoactivated Adenylyl Cyclases.Cell chemical biology · 2019
   Article
9. Reduced deformability contributes to impaired deoxygenation-induced ATP release from red blood cells of older adult humans.The Journal of physiology · 2019
   Article
10. Distinct Spatiotemporal Distribution of Bacterial Toxin-Produced Cellular cAMP Differentially Inhibits Opsonophagocytic Signaling.Toxins · 2019
    Article
11. Inhibition of NaThe Journal of physiology · 2018
    Article
12. Phosphatases control PKA-dependent functional microdomains at the outer mitochondrial membrane.Proceedings of the National Academy of Sciences of the United States of America · 2018
    Article
13. Functional Significance of the Adcy10-Dependent Intracellular cAMP Compartments.Journal of cardiovascular development and disease · 2018
    Review
14. The Development of Compartmentation of cAMP Signaling in Cardiomyocytes: The Role of T-Tubules and Caveolae Microdomains.Journal of cardiovascular development and disease · 2018
    Review
15. Compartmentalized Cyclic AMP Production by theFrontiers in immunology · 2018
    Article
16. Modulation of cyclic nucleotide-mediated cellular signaling and gene expression using photoactivated adenylyl cyclase as an optogenetic tool.Scientific reports · 2017
    Article
17. Modulation of Compartmentalised Cyclic Nucleotide Signalling via Local Inhibition of Phosphodiesterase Activity.International journal of molecular sciences · 2016
    Review
18. Dysregulation of Neuronal Ca2+ Channel Linked to Heightened Sympathetic Phenotype in Prohypertensive States.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016
    Article
19. Intracellular tortuosity underlies slow cAMP diffusion in adult ventricular myocytes.Cardiovascular research · 2016
    Article
20. Modulation of Polycystic Kidney Disease Severity by Phosphodiesterase 1 and 3 Subfamilies.Journal of the American Society of Nephrology : JASN · 2016
    Article

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

Authors and funding

2 authors.

Funding

Abstract

Indexed as