ArticleThe Journal of cell biology1988
Use of monospecific antisera and cRNA probes to localize the major changes in keratin expression during normal and abnormal epidermal differentiation.
Article in The Journal of cell biology, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 104 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
104 citing papers in PubMed, 357 citations in OpenAlex.
- Keratin 15 promotes a progenitor cell state in basal keratinocytes of skin epidermis.The Journal of cell biology · 2026Article
- Bacterial Pyocyanin Inducible Keratin 6A Accelerates Closure of Epithelial Defect under Conditions of Mitochondrial Dysfunction.The Journal of investigative dermatology · 2023Article
- Revisiting the significance of keratin expression in complex epithelia.Journal of cell science · 2022Article
- KLF5 governs sphingolipid metabolism and barrier function of the skin.Genes & development · 2022Article
- Transcriptomic insight into the translational value of two murine models in human atopic dermatitis.Scientific reports · 2021Article
- Serum lipids, retinoic acid and phenol red differentially regulate expression of keratins K1, K10 and K2 in cultured keratinocytes.Scientific reports · 2020Article
- Keratinocyte-specific ablation of Mcpip1 impairs skin integrity and promotes local and systemic inflammation.Journal of molecular medicine (Berlin, Germany) · 2019Article
- The monoclonal antibody EPR1614Y against the stem cell biomarker keratin K15 lacks specificity and reacts with other keratins.Scientific reports · 2019Article
- IRF6 and AP2A Interaction Regulates Epidermal Development.The Journal of investigative dermatology · 2018Article
- IRF6 expression in basal epithelium partially rescues Irf6 knockout mice.Developmental dynamics : an official publication of the American Association of Anatomists · 2017Article
- TCF7L1 promotes skin tumorigenesis independently of β-catenin through induction of LCN2.eLife · 2017Article
- Formation of keratinocyte multilayers on filters under airlifted or submerged culture conditions in medium containing calcium, ascorbic acid, and keratinocyte growth factor.Histochemistry and cell biology · 2016Article
- Skin Keratins.Methods in enzymology · 2016Article
- Over-expression of Plk4 induces centrosome amplification, loss of primary cilia and associated tissue hyperplasia in the mouse.Open biology · 2015Article
- Atypical Protein Kinase C Isoform, aPKCλ, Is Essential for Maintaining Hair Follicle Stem Cell Quiescence.The Journal of investigative dermatology · 2015Article
- A role for microRNA-155 expression in microenvironment associated to HPV-induced carcinogenesis in K14-HPV16 transgenic mice.PloS one · 2015Article
- Notch signaling may be involved in the abnormal differentiation of epidermal keratinocytes in psoriasis.Acta histochemica et cytochemica · 2014Article
- Downregulation of STRA6 expression in epidermal keratinocytes leads to hyperproliferation-associated differentiation in both in vitro and in vivo skin models.The Journal of investigative dermatology · 2014Article
- Topical hypochlorite ameliorates NF-κB-mediated skin diseases in mice.The Journal of clinical investigation · 2013Article
- Sphingosine-1-phosphate phosphatase 1 regulates keratinocyte differentiation and epidermal homeostasis.The Journal of biological chemistry · 2013Article
44 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We report here the isolation and characterization of three antisera, each of which is specific for a single keratin from one of the three different pairs (K1/K10, K14/K5, K16/K6) that are differentially expressed in normal human epidermis and in epidermal diseases of hyperproliferation. We have used these antisera in conjunction with monospecific cRNA probes for epidermal keratin mRNAs to investigate pathways of differentiation in human epidermis and epidermal diseases in vivo and in epidermal cells cultured from normal skin and from squamous cell carcinomas in vitro. Specifically, our results suggest that: (a) the basal-specific keratin mRNAs are down-regulated upon commitment to terminal differentiation, but their encoded proteins are stable, and can be detected throughout the spinous layers; (b) the hyperproliferation-associated keratin mRNAs are expressed at a low level throughout normal epidermis when their encoded proteins are not expressed, but are synthesized at high levels in the suprabasal layers of hyperproliferating epidermis, coincident with the induced expression of the hyperproliferation-associated keratins in these cells; and (c) concomitantly with the induction of the hyperproliferation-associated keratins in the suprabasal layers of the epidermis is the down-regulation of the expression of the terminal differentiation-specific keratins. These data have important implications for our understanding of normal epidermal differentiation and the deviations from this process in the course of epidermal diseases of hyperproliferation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.