ArticleThe Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation2014
Assessment of myocardial viability and left ventricular function in patients supported by a left ventricular assist device.
Article in The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Initiation of Neurohormonal Blockade and Clinical Outcomes in HeartMate 3 LVAD Recipients During Index Implantation.Artificial organs · 2026Article
- Mechanisms and Therapeutic Potential of Human Cardiomyocyte Proliferation.Journal of cardiovascular development and disease · 2026Review
- Myocardial Recovery.Diagnostics (Basel, Switzerland) · 2023Review
- Defining cardiac functional recovery in end-stage heart failure at single-cell resolution.Nature cardiovascular research · 2023Article
- LVAD as a Bridge to Remission from Advanced Heart Failure: Current Data and Opportunities for Improvement.Journal of clinical medicine · 2022Review
- Role of Echocardiography in the Management of Patients with Advanced (Stage D) Heart Failure Related to Nonischemic Cardiomyopathy.Reviews in cardiovascular medicine · 2022Review
- Weaning from ventricular assist device support after recovery from left ventricular failure with or without secondary right ventricular failure.Cardiovascular diagnosis and therapy · 2021Review
- Ultrasound-based estimation of remaining cardiac function in LVAD-supported ex vivo hearts.Artificial organs · 2020Article
- Expanding the Scope of Multimodality Imaging in Durable Mechanical Circulatory Support.JACC. Cardiovascular imaging · 2020Review
- Role of Echocardiography in the Evaluation of Left Ventricular Assist Devices: the Importance of Emerging Technologies.Current cardiology reports · 2016Review
- Imaging in patients after cardiac transplantation and in patients with ventricular assist devices.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2015Review
- Human ventricular unloading induces cardiomyocyte proliferation.Journal of the American College of Cardiology · 2015Article
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Authors and funding
15 authors.
Funding
Abstract
backgroundChronically supported left ventricular assist device (LVAD) patients may be candidates for novel therapies aimed at promoting reverse remodeling and myocardial recovery. However, the effect of hemodynamic unloading with a LVAD on myocardial viability and LV function in chronically supported LVAD patients has not been fully characterized. We aimed to develop a non-invasive imaging protocol to serially quantify native cardiac structure, function, and myocardial viability while at reduced LVAD support.
methodsClinically stable (n = 18) ambulatory patients (83% men, median age, 61 years) supported by a HeartMate II (Thoratec, Pleasanton, CA) LVAD (median durations of heart failure 4.6 years and LVAD support 7 months) were evaluated by echocardiography and technetium-99m ((99m)Tc)-sestamibi single photon emission computed tomography (SPECT) imaging at baseline and after an interval of 2 to 3 months. Echocardiographic measures of LV size and function, including speckle tracking-derived circumferential strain, were compared between ambulatory and reduced LVAD support at baseline and between baseline and follow-up at reduced LVAD support. The extent of myocardial viability by SPECT was compared between baseline and follow-up at reduced LVAD support.
resultsWith reduction in LVAD speeds (6,600 rpm; interquartile range: 6,200, 7,400 rpm), LV size increased, LV systolic function remained stable, and filling pressures nominally worsened. After a median 2.1 months, cardiac structure, function, and the extent of viable myocardium, globally and regionally, was unchanged on repeat imaging while at reduced LVAD speed.
conclusionsIn clinically stable chronically supported LVAD patients, intrinsic cardiac structure, function, and myocardial viability did not significantly change over the pre-specified time frame. Echocardiographic circumferential strain and (99m)Tc-sestamibi SPECT myocardial viability imaging may provide useful non-invasive end points for the assessment of cardiac structure and function, particularly for phase II studies of novel therapies aimed at promoting reverse remodeling and myocardial recovery in LVAD patients.
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