Evidence map›Paper›PMID 24582682›Full record

ArticleFood and chemical toxicology : an international journal published for the British Industrial Biological Research Association2014

Reproductive toxicity in rats with crystal nephropathy following high doses of oral melamine or cyanuric acid.

Cynthia B Stine, Renate Reimschuessel, Zachary Keltner, Cristina B Nochetto, Thomas Black, Nicholas Olejnik, Michael Scott, Omari Bandele, Sarah M Nemser, Andriy Tkachenko and 6 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
9.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 45 citations in OpenAlex.

  1. Article
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  5. Review
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  10. Use of urinary renal biomarkers to evaluate the nephrotoxic effects of melamine or cyanuric acid in non-pregnant and pregnant rats.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2014
    Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 2 institutions in 1 country.

Cynthia B StineCenter for Veterinary Medicine, US Food and Drug Administration, 8401 Muirkirk Rd, Laurel, MD 20708, USA. Electronic address: cynthia.stine@fda.hhs.gov.
Renate ReimschuesselCenter for Veterinary Medicine, US Food and Drug Administration, 8401 Muirkirk Rd, Laurel, MD 20708, USA. Electronic address: renate.reimschuessel@fda.hhs.gov.
Zachary KeltnerCenter for Food Safety and Applied Nutrition, US Food and Drug Administration, 8301 Muirkirk Rd, Laurel, MD 20708, USA. Electronic address: zachary.keltner@fda.hhs.gov.
Cristina B NochettoCenter for Veterinary Medicine, US Food and Drug Administration, 8401 Muirkirk Rd, Laurel, MD 20708, USA. Electronic address: cristina.nochetto@fda.hhs.gov.
Thomas BlackCenter for Food Safety and Applied Nutrition, US Food and Drug Administration, 8301 Muirkirk Rd, Laurel, MD 20708, USA. Electronic address: thomas.black@fda.hhs.gov.
Nicholas OlejnikCenter for Food Safety and Applied Nutrition, US Food and Drug Administration, 8301 Muirkirk Rd, Laurel, MD 20708, USA. Electronic address: nicholas.olejnik@fda.hhs.gov.
Michael ScottCenter for Food Safety and Applied Nutrition, US Food and Drug Administration, 8301 Muirkirk Rd, Laurel, MD 20708, USA. Electronic address: michael.scott@fda.hhs.gov.
Omari BandeleCenter for Food Safety and Applied Nutrition, US Food and Drug Administration, 8301 Muirkirk Rd, Laurel, MD 20708, USA. Electronic address: omari.bandele@fda.hhs.gov.
Sarah M NemserCenter for Veterinary Medicine, US Food and Drug Administration, 8401 Muirkirk Rd, Laurel, MD 20708, USA. Electronic address: sarah.nemser@fda.hhs.gov.
Andriy TkachenkoCenter for Veterinary Medicine, US Food and Drug Administration, 8401 Muirkirk Rd, Laurel, MD 20708, USA. Electronic address: andriy.tkachenko@fda.hhs.gov.
Eric R EvansCenter for Veterinary Medicine, US Food and Drug Administration, 8401 Muirkirk Rd, Laurel, MD 20708, USA. Electronic address: eric.evans@fda.hhs.gov.
Tina C CrosbyCenter for Veterinary Medicine, US Food and Drug Administration, 8401 Muirkirk Rd, Laurel, MD 20708, USA. Electronic address: tina.crosby@fda.hhs.gov.
Olgica CericCenter for Veterinary Medicine, US Food and Drug Administration, 8401 Muirkirk Rd, Laurel, MD 20708, USA. Electronic address: olgica.ceric@fda.hhs.gov.
Martine FergusonCenter for Food Safety and Applied Nutrition, US Food and Drug Administration, 8301 Muirkirk Rd, Laurel, MD 20708, USA. Electronic address: martine.ferguson@fda.hhs.gov.
Betsy J YakesCenter for Food Safety and Applied Nutrition, US Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20740, USA. Electronic address: betsy.yakes@fda.hhs.gov.
Robert SprandoCenter for Food Safety and Applied Nutrition, US Food and Drug Administration, 8301 Muirkirk Rd, Laurel, MD 20708, USA. Electronic address: robert.sprando@fda.hhs.gov.
Center for Food Safety and Applied Nutrition · USCenter for Veterinary Medicine · US

Funding

Intramural FDA HHS FD999999
6 · The paper itself

Abstract

The industrial chemical melamine was used in 2007 and 2008 to raise the apparent protein content in pet feed and watered down milk, respectively. Because humans may be exposed to melamine via several different routes into the human diet as well as deliberate contamination, this study was designed to characterize the effect of high dose melamine or cyanuric acid oral exposure on the pregnant animal and developing fetus, including placental transfer. Clear rectangular crystals formed following a single triazine exposure which is a different morphology from the golden spherulites caused by combined exposure or the calculi formed when melamine combines with endogenous uric acid. Crystal nephropathy, regardless of cause, induces renal failure which in turn has reproductive sequelae. Specifically, melamine alone-treated dams had increased numbers of early and late fetal deaths compared to controls or cyanuric acid-treated dams. As melamine was found in the amniotic fluid, this study confirms transfer of melamine from mammalian mother to fetus and our study provides evidence that cyanuric acid also appears in the amniotic fluid if mothers are exposed to high doses.

Indexed as

Maternal ExposureAdministration, OralAnimal FeedAnimalsBlood Urea NitrogenBody WeightCreatinineDose-Response Relationship, DrugFemaleFood ContaminationMaleOrgan SizeRatsRenal InsufficiencyReproductionToxicity TestsCreatininecyanuric acidmelamineTriazinesCyanuric acidMelamineRatsReproductive toxicity

Identifiers

PMID24582682
PMCPMC11421684
OpenAlexW2032992371

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.