ArticlePhysiology & behavior2014
Post-oral fat stimulation of intake and conditioned flavor preference in C57BL/6J mice: A concentration-response study.
Article in Physiology & behavior, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A systematic review of the biological mediators of fat taste and smell.Physiological reviews · 2023Pooled it
- Functional segregation of body-brain signals in the area postrema.bioRxiv : the preprint server for biology · 2026Article
- A lateralized pathway for associating nutrients with flavors.bioRxiv : the preprint server for biology · 2025Article
- Fat taste responsiveness, but not dietary fat intake, is affected inbioRxiv : the preprint server for biology · 2025Article
- Fat preference deficits and experience-induced recovery in global taste-deficient Trpm5 and Calhm1 knockout mice.Physiology & behavior · 2022Article
- Post-oral sensing of fat increases food intake and attenuates body weight defense.Cell reports · 2021Article
- Learning of food preferences: mechanisms and implications for obesity & metabolic diseases.International journal of obesity (2005) · 2021Review
- Learning of food preferences: mechanisms and implications for obesity & metabolic diseases.International journal of obesity (2005) · 2021Review
- Residual Glucose Taste in T1R3 Knockout but not TRPM5 Knockout Mice.Physiology & behavior · 2020Article
- Capsaicin-induced visceral deafferentation does not attenuate flavor conditioning by intragastric fat infusions in mice.Physiology & behavior · 2019Article
- Greater reductions in fat preferences in CALHM1 than CD36 knockout mice.American journal of physiology. Regulatory, integrative and comparative physiology · 2018Article
- Role of lipolysis in postoral and oral fat preferences in mice.American journal of physiology. Regulatory, integrative and comparative physiology · 2018Article
- From appetite setpoint to appetition: 50years of ingestive behavior research.Physiology & behavior · 2018Review
- Gut-brain nutrient sensing in food reward.Appetite · 2018Review
- Proceedings of the 2015 ASPEN Research Workshop-Taste Signaling.JPEN. Journal of parenteral and enteral nutrition · 2017Article
- Behavioral Evidence for More than One Taste Signaling Pathway for Sugars in Rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Ghrelin signaling is not essential for sugar or fat conditioned flavor preferences in mice.Physiology & behavior · 2015Article
- Intragastric fat self-administration is impaired in GPR40/120 double knockout mice.Physiology & behavior · 2015Article
- Does nutrient sensing determine how we "see" food?Current diabetes reports · 2015Review
- Flavor change and food deprivation are not critical for post-oral glucose appetition in mice.Physiology & behavior · 2015Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Fat appetite is determined not only by orosensory (flavor) stimuli but also by the post-oral actions of dietary fat, which promote increased attraction to the flavors of high-fat foods. Experiment 1 presents a concentration-response analysis of how intragastric (IG) fat self-infusions stimulate intake and condition flavor preferences in C57BL/6J mice trained 1h/day. Separate groups of food-restricted mice consumed a flavored saccharin solution (the CS-) paired with IG self-infusions of water (Test 0) followed by a different flavored solution (the CS+) paired with IG self-infusions of 1.6, 3.2, 6.4 or 12.8% Intralipid (IL, soybean oil) (Tests 1-3). Following additional CS- and CS+ training sessions, a two-bottle CS+ vs. CS- choice test was conducted without infusions. Infusions of 3.2-12.8% IL stimulated CS+ licking in the first test session and more so in subsequent test sessions, and also conditioned significant CS+ preferences. These effects were similar to those previously observed with isocaloric glucose infusions (8-32%). IG infusion of 1.6% IL stimulated intake slightly but did not condition a CS+ preference comparable to the actions of isocaloric 4% glucose. Experiment 2 compared these subthreshold IL and glucose concentrations with that of a 1.6% IL+4% glucose infusion. This mixture stimulated 1-h CS+ licking more rapidly but generated a preference similar to that of 1.6% IL. In 23h/day tests, however, the IL+glucose mixture stimulated greater CS+ intakes and preferences than did 1.6% IL or 4% glucose. These findings show that fat, like glucose, rapidly generates concentration-dependent post-oral signals that stimulate intake and enhance preferences for energy-rich foods in mice.
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