Evidence map›Paper›PMID 24582666›Full record

ReviewMatrix biology : journal of the International Society for Matrix Biology2014

Invoking the power of thrombospondins: regulation of thrombospondins expression.

Olga Stenina-Adognravi

Abstract readReview
In one paragraph

Review in Matrix biology : journal of the International Society for Matrix Biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Activation-induced thrombospondin-4 works with thrombospondin-1 to build cytotoxic supramolecular attack particles.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Review
  16. Matricellular proteins in cutaneous wound healing.Frontiers in cell and developmental biology · 2022
    Review
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Olga Stenina-AdognraviDepartment of Molecular Cardiology, Cleveland Clinic, 9500 Euclid Ave NB50, Cleveland, OH 44195, United States. Electronic address: stenino@ccf.org.

Funding

TSP-4 genetic variants in atherogenesis and angiogenesisR01HL117216 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI PLOW, EDWARD FRANKLIN, STENINA, OLGA I · 2013 to 2017
$1.9M
Tissue Specific Regulation of Diabetes-Associated Cancer GrowthR01CA177771 · NCI · CLEVELAND CLINIC LERNER COM-CWRU · PI STENINA, OLGA I · 2014 to 2018
$1.6M
Regulation of thrombospondin-1 expression by glucoseR01DK067532 · NIDDK · CLEVELAND CLINIC LERNER COM-CWRU · PI STENINA, OLGA I · 2006 to 2010
$1.4M
NCI NIH HHS R01 CA177771NHLBI NIH HHS R01 HL117216NIDDK NIH HHS R01 DK067532
6 · The paper itself

Abstract

Increasing evidence suggests critical functions of thrombospondins (TSPs) in a variety of physiological and pathological processes. With the growing understanding of the importance of these matricellular proteins, the need to understand the mechanisms of regulation of their expression and potential approaches to modulate their levels is also increasing. The regulation of TSP expression is multi-leveled, cell- and tissue-specific, and very precise. However, the knowledge of mechanisms modulating the levels of TSPs is fragmented and incomplete. This review discusses the known mechanisms of regulation of TSP levels and the gaps in our knowledge that prevent us from developing strategies to modulate the expression of these physiologically important proteins.

Indexed as

Alternative SplicingAnimalsBase SequenceEmbryo, MammalianExtracellular Matrix ProteinsFibronectinsGene Expression Regulation, DevelopmentalHumansMiceMolecular Sequence DataOsteonectinProtein Structure, TertiarySpecies SpecificityTenascinThrombospondinsExtracellular Matrix ProteinsFibronectinsOsteonectinSPARC protein, humanTenascinThrombospondinsmiRNARegulation of expressionThrombospondinTranscriptionTranslation

Identifiers

PMID24582666
PMCPMC4143502

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.