ArticlePhysiology & behavior2014
A mutation causing increased KATP channel activity leads to reduced anxiety in mice.
Article in Physiology & behavior, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed.
- Chronic Ethanol Exposures Leads to a Negative Affective State in Female Rats That Is Accompanied by a Paradoxical Decrease in Ventral Hippocampus Excitability.Frontiers in neuroscience · 2021Article
- Modulation of SUR1 KInternational journal of molecular sciences · 2019Article
- Chronic Intermittent Ethanol Exposure Selectively Increases Synaptic Excitability in the Ventral Domain of the Rat Hippocampus.Neuroscience · 2019Article
- Future Roadmaps for Precision Medicine Applied to Diabetes: Rising to the Challenge of Heterogeneity.Journal of diabetes research · 2018Review
- KInternal medicine (Tokyo, Japan) · 2017Review
- Neonatal Diabetes and the KTrends in endocrinology and metabolism: TEM · 2017Review
- Purinergic Signalling: Therapeutic Developments.Frontiers in pharmacology · 2017Review
- Psychiatric morbidity in children with KCNJ11 neonatal diabetes.Diabetic medicine : a journal of the British Diabetic Association · 2016Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Activating mutations in the Kir6.2 (KCNJ11) subunit of the ATP-sensitive potassium channel cause neonatal diabetes. Many patients also suffer from neurological complications. By using mice carrying a human Kir6.2 mutation (Val(59) to Met(59); nV59M mice) targeted to neurones, we show that these mutations also result in altered anxiety behaviour. The light/dark box, successive alleys and elevated plus maze tasks revealed that nV59M mice have reduced anxiety related responses. Additionally, nV59M mice displayed enhanced basal locomotor activity and exploratory behaviour, as assessed by the low anxiety open-field test. These findings, in combination with previously reported hyperactivity of nV59M mice, appear to correlate with the increased impulsivity and inattentiveness reported in iDEND/DEND patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.