ArticleMagnetic resonance imaging2014
DTI-based segmentation and quantification of human brain lateral ventricular CSF volumetry and mean diffusivity: validation, age, gender effects and biophysical implications.
Article in Magnetic resonance imaging, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Genome-wide association study of 23,500 individuals identifies 7 loci associated with brain ventricular volume.Nature communications · 2018Pooled it
- PPAR-gamma agonist pioglitazone modifies craving intensity and brain white matter integrity in patients with primary cocaine use disorder: a double-blind randomized controlled pilot trial.Addiction (Abingdon, England) · 2017Trial
- Mapping the aggregate g-ratio of white matter tracts using multi-modal MRI.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Image data harmonization tools for the analysis of post-traumatic epilepsy development in preclinical multisite MRI studies.Epilepsy research · 2023Article
- Cortical Structure Differences in Relation to Age, Sexual Attractions, and Gender Dysphoria in Adolescents: An Examination of Mean Diffusivity and T1 Relaxation Time.Brain sciences · 2023Article
- Altered diffusivity of the subarachnoid cisterns in the rat brain following neurological disorders.Biomedical journal · 2023Article
- Long-term environmental enrichment is associated with better fornix microstructure in older adults.Frontiers in aging neuroscience · 2023Article
- DWI-based MR thermometry: could it discriminate Alzheimer's disease from mild cognitive impairment and healthy subjects?Neuroradiology · 2022Article
- Classification Algorithms for Brain Magnetic Resonance Imaging Images of Patients with End-Stage Renal Disease and Depression.Contrast media & molecular imaging · 2022Article
- Optimal strategy for measuring intraventricular temperature using acceleration motion compensation diffusion-weighted imaging.Radiological physics and technology · 2020Article
- Article
- Brain-core temperature of patients before and after orthotopic liver transplantation assessed by DWI thermometry.Japanese journal of radiology · 2018Article
- Assessment of brain core temperature using MR DWI-thermometry in Alzheimer disease patients compared to healthy subjects.Japanese journal of radiology · 2017Article
- Lateral ventricular cerebrospinal fluid diffusivity as a potential neuroimaging marker of brain temperature in multiple sclerosis: a hypothesis and implications.Magnetic resonance imaging · 2015Article
- Relationships between quantitative spinal cord MRI and retinal layers in multiple sclerosis.Neurology · 2015Article
- Comparison of Neurocognitive Testing and the Measurement of Marinobufagenin in Mild Traumatic Brain Injury: A Preliminary Report.Journal of experimental neuroscience · 2015Article
- Brain core temperature of patients with mild traumatic brain injury as assessed by DWI-thermometry.Neuroradiology · 2014Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The human brain lateral ventricular (LV) cerebrospinal fluid (CSF) volume has been used as a neuroimaging marker of brain changes in health and disease. The LV CSF diffusivity may offer a useful quality assurance measure and become a potential noninvasive marker of deep brain temperature. In this work we sought to validate a method for human brain lateral ventricular (LV) cerebrospinal fluid (CSF) using diffusion tensor imaging (DTI) contrast to provide LV volume and corresponding DTI metrics. We compared LV volume obtained using DTI with that obtained using validated segmentations of the LV on T1-weighted data. DTI and T1-weighted data were acquired at 3T on 49 healthy males and 56 age-matched females aged 18-59 years. We showed histogram distributions of LV DTI metrics to establish quality assurance measures. We also analyzed the age and gender effects of LV volume and diffusivity. LV volumes estimated using both T1-weighted and DTI correlated strongly in males and females (ICC=0.99; median Dice index ~80%). The LV-to-intracranial volume percentage increased significantly with age only in males, using the DTI-based approach (r=0.39; p=0.005). LV CSF Mean diffusivity was greater in males than females ((~1.2%; p=0.03). Mean diffusivity of lateral ventricular CSF decreased significantly with age in healthy adults (r=-0.30; p=0.02). Our results highlight the importance of age and gender-based analyses and the potential of LV diffusivity measures as a quantitative marker.
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