Evidence map›Paper›PMID 24582000›Full record

ArticleJournal of neuroimmunology2014

Activated microglia do not form functional gap junctions in vivo.

Sameh K Wasseff, Steven S Scherer

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuroimmunology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Review
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  7. Review
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  9. Review
  10. Connexins and Disease.Cold Spring Harbor perspectives in biology · 2018
    Review
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  12. Review
  13. Article
  14. Review
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  17. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Sameh K WasseffDepartment of Neurology, The Perelman School of Medicine at the University of Pennsylvania, United States. Electronic address: swasseff@mail.med.upenn.edu.
Steven S SchererDepartment of Neurology, The Perelman School of Medicine at the University of Pennsylvania, United States. Electronic address: sscherer@mail.med.upenn.edu.

Funding

The Role of Connexin32 in the Pathogensis of CMTXR01NS055284 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI SCHERER, STEVEN SIMON · 2007 to 2016
$2.9M
NINDS NIH HHS R01 NS055284
6 · The paper itself

Abstract

We investigated whether microglia form gap junctions with themselves, or with astrocytes, oligodendrocytes, or neurons in vivo in normal mouse brains, and in pathological conditions that induce microglial activation - brain injury and a model of Alzheimer's disease. Although microglia are in close physical proximity to glia and neurons, they do not form functional gap junctions under these pathological conditions.

Indexed as

Alzheimer DiseaseAnimalsBrain InjuriesGap JunctionsHumansMiceMice, 129 StrainMice, Inbred C57BLMice, TransgenicMicrogliaOrgan Culture TechniquesAlzheimer's diseaseAstrocytesBrain injuryGap junctionsMicrogliaOligodendrocytes

Identifiers

PMID24582000
PMCPMC4048983

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.