Evidence map›Paper›PMID 24581860›Full record

ArticleArchives of oral biology2014

Gene expression based evidence of innate immune response activation in the epithelium with oral lichen planus.

Guy R Adami, Alexander C F Yeung, Grant Stucki, Antonia Kolokythas, Herve Y Sroussi, Robert J Cabay, Igor Kuzin, Joel L Schwartz

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Archives of oral biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Oral lichen planus: a microbiologist point of view.International microbiology : the official journal of the Spanish Society for Microbiology · 2021
    Review
  5. Article
  6. Lichen Planus.Frontiers in medicine · 2021
    Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Guy R AdamiDepartment of Oral Medicine and Oral Diagnostics, Center for Molecular Biology of Oral Diseases, University of Illinois at Chicago, 801 South Paulina Street, Chicago, IL 60612, USA. Electronic address: gadami@uic.edu.
Alexander C F YeungDepartment of Oral Medicine and Oral Diagnostics, Center for Molecular Biology of Oral Diseases, University of Illinois at Chicago, 801 South Paulina Street, Chicago, IL 60612, USA.
Grant StuckiDepartment of Oral and Maxillofacial Surgery, College of Dentistry, University of Illinois at Chicago, 801 South Paulina Street, Chicago, IL 60612, USA.
Antonia KolokythasDepartment of Oral and Maxillofacial Surgery, College of Dentistry, University of Illinois at Chicago, 801 South Paulina Street, Chicago, IL 60612, USA.
Herve Y SroussiDepartment of Oral Medicine and Oral Diagnostics, Center for Molecular Biology of Oral Diseases, University of Illinois at Chicago, 801 South Paulina Street, Chicago, IL 60612, USA.
Robert J CabayDepartment of Pathology, College of Medicine, University of Illinois at Chicago, 840 South Wood Street, Chicago, IL 60612, USA.
Igor KuzinDivision of Allergy/Immunology and Rheumatology, School of Medicine and Dentistry, University of Rochester, 601 Elmwood Avenue, Rochester, NY 14642, USA.
Joel L SchwartzDepartment of Oral Medicine and Oral Diagnostics, Center for Molecular Biology of Oral Diseases, University of Illinois at Chicago, 801 South Paulina Street, Chicago, IL 60612, USA.
University of Illinois Chicago · USUniversity of Rochester · US

Funding

RNA from Brush Cytology to Detect Squamous Cell CarcinomaR21CA139137 · NCI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI SCHWARTZ, JOEL L · 2010 to 2011
$371k
RNA from Brush Cytology to Identify Aggressive Squamous Cell CarcinomaR03CA150076 · NCI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI ADAMI, GUY RICHARD, SCHWARTZ, JOEL L · 2012 to 2013
$155k
NCI NIH HHS R03 CA150076NCI NIH HHS R03CA150076NCI NIH HHS R21 CA139137NCI NIH HHS R21CA139137
6 · The paper itself

Abstract

objectiveOral lichen planus (OLP) is a disease of the oral mucosa of unknown cause producing lesions with an intense band-like inflammatory infiltrate of T cells to the subepithelium and keratinocyte cell death. We performed gene expression analysis of the oral epithelium of lesions in subjects with OLP and its sister disease, oral lichenoid reaction (OLR), in order to better understand the role of the keratinocytes in these diseases.

designFourteen patients with OLP or OLR were included in the study, along with a control group of 23 subjects with a variety of oral diseases and a normal group of 17 subjects with no clinically visible mucosal abnormalities. Various proteins have been associated with OLP, based on detection of secreted proteins or changes in RNA levels in tissue samples consisting of epithelium, stroma, and immune cells. The mRNA level of twelve of these genes expressed in the epithelium was tested in the three groups.

resultsFour genes showed increased expression in the epithelium of OLP patients: CD14, CXCL1, IL8, and TLR1, and at least two of these proteins, TLR1 and CXCL1, were expressed at substantial levels in oral keratinocytes.

conclusionsBecause of the large accumulation of T cells in lesions of OLP it has long been thought to be an adaptive immunity malfunction. We provide evidence that there is increased expression of innate immune genes in the epithelium with this illness, suggesting a role for this process in the disease and a possible target for treatment.

Indexed as

Gene ExpressionAdolescentAdultAgedCase-Control StudiesChemokine CXCL1Epithelial CellsFemaleHumansImmunoenzyme TechniquesInterleukin-8Lichen Planus, OralLipopolysaccharide ReceptorsMaleMiddle AgedReverse Transcriptase Polymerase Chain ReactionChemokine CXCL1CXCL1 protein, humanInterleukin-8Lipopolysaccharide ReceptorsToll-Like Receptor 1EpitheliumGene expressionInnate immunityLichen planusRNA

Identifiers

PMID24581860
PMCPMC5424530
OpenAlexW2014514465

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.