ArticleAmerican journal of human genetics2014
An expressed retrogene of the master embryonic stem cell gene POU5F1 is associated with prostate cancer susceptibility.
Article in American journal of human genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 35 citations in OpenAlex.
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- Global and China burden of hormone-related cancers and risk factors, 1990-2021: results from the Global Burden of Disease Study 2021.BMC public health · 2025Article
- Coding Variants of the Genitourinary Development GeneJCO precision oncology · 2025Article
- Considering hormone-sensitive cancers as a single disease in the UK biobank reveals shared aetiology.Communications biology · 2022Article
- Exploring the effects of genetic variation on gene regulation in cancer in the context of 3D genome structure.BMC genomic data · 2022Article
- Prostate cancer risk variants of the HOXB genetic locus.Scientific reports · 2021Article
- Boosting GWAS using biological networks: A study on susceptibility to familial breast cancer.PLoS computational biology · 2021Article
- Review
- 8q24 genetic variation and comprehensive haplotypes altering familial risk of prostate cancer.Nature communications · 2020Article
- Practical genotyping by single-nucleotide primer extension.Biology methods & protocols · 2020Article
- Low Expression of Pseudogene POU5F1B Affects Diagnosis and Prognosis in Acute Myeloid Leukemia (AML).Medical science monitor : international medical journal of experimental and clinical research · 2019Article
- Deletion of the murine ortholog of the 8q24 gene desert has anti-cancer effects in transgenic mammary cancer models.BMC cancer · 2018Article
- Role of Pseudogenes in Tumorigenesis.Cancers · 2018Review
- Effect of silencing colon cancer-associated transcript 2 on the proliferation, apoptosis and autophagy of gastric cancer BGC-823 cells.Oncology letters · 2018Article
- Article
- Prospective study of DNA methylation at chromosome 8q24 in peripheral blood and prostate cancer risk.British journal of cancer · 2017Article
- Comprehensive Genetic Landscape of Uveal Melanoma by Whole-Genome Sequencing.American journal of human genetics · 2016Article
- Three new pancreatic cancer susceptibility signals identified on chromosomes 1q32.1, 5p15.33 and 8q24.21.Oncotarget · 2016Article
- Akt‑mediated phosphorylation of Oct4 is associated with the proliferation of stem‑like cancer cells.Oncology reports · 2015Article
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13 authors at 3 institutions in 2 countries.
Funding
Abstract
Genetic association studies of prostate and other cancers have identified a major risk locus at chromosome 8q24. Several independent risk variants at this locus alter transcriptional regulatory elements, but an affected gene and mechanism for cancer predisposition have remained elusive. The retrogene POU5F1B within the locus has a preserved open reading frame encoding a homolog of the master embryonic stem cell transcription factor Oct4. We find that 8q24 risk alleles are expression quantitative trait loci correlated with reduced expression of POU5F1B in prostate tissue and that predicted deleterious POU5F1B missense variants are also associated with risk of transformation. POU5F1 is known to be self-regulated by the encoded Oct4 transcription factor. We further observe that POU5F1 expression is directly correlated with POU5F1B expression. Our results suggest that a pathway critical to self-renewal of embryonic stem cells may also have a role in the origin of cancer.
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