Evidence map›Paper›PMID 24581689›Full record

ReviewCurrent opinion in microbiology2014

Structural organisation of the type IV secretion systems.

Gabriel Waksman, Elena V Orlova

Open access · hybridAbstract readReview
In one paragraph

Review in Current opinion in microbiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
5.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 31 citations in OpenAlex.

  1. Biology · 2025
    Review
  2. Article
  3. Genetic Profiling ofPathogens (Basel, Switzerland) · 2019
    Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Gabriel WaksmanInstitute of Structural and Molecular Biology, UCL and Birkbeck College, Malet Street, WC1E 7HX London, UK. Electronic address: g.waksman@mail.cryst.bbk.ac.uk.
Elena V OrlovaInstitute of Structural and Molecular Biology, UCL and Birkbeck College, Malet Street, WC1E 7HX London, UK. Electronic address: e.orlova@mail.cryst.bbk.ac.uk.
Birkbeck, University of London · GB

Funding

Medical Research Council K012401Medical Research Council MR/K012401/1Wellcome Trust 082227
6 · The paper itself

Abstract

Type IV secretion (T4S) systems are large dynamic nanomachines that transport DNAs and/or proteins through the membranes of bacteria. Because of their complexity and multi-protein organisation, T4S systems have been extremely challenging to study structurally. However in the past five years significant milestones have been achieved by X-ray crystallography and cryo-electron microscopy. This review describes some of the more recent advances: the structures of some of the protein components of the T4S systems and the complete core complex structure that was determined using electron microscopy.

Indexed as

Bacterial ProteinsBacterial Secretion SystemsDNA, BacterialMicroscopy, ElectronModels, MolecularBacterial ProteinsBacterial Secretion SystemsDNA, Bacterial

Identifiers

PMID24581689
PMCPMC3969286
OpenAlexW2065902484

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.