Evidence map›Paper›PMID 24581687›Full record

ReviewCurrent opinion in microbiology2014

Genetic systems for studying obligate intracellular pathogens: an update.

David O Wood, Raphael R Wood, Aimee M Tucker

Abstract readReview
In one paragraph

Review in Current opinion in microbiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. ACS infectious diseases · 2022
    Article
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  6. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

David O WoodLaboratory of Molecular Biology, Department of Microbiology and Immunology, College of Medicine, University of South Alabama, 501 Aubrey Green Drive, Mobile, AL 36688-0002, United States. Electronic address: dowood@southalabama.edu.
Raphael R WoodLaboratory of Molecular Biology, Department of Microbiology and Immunology, College of Medicine, University of South Alabama, 501 Aubrey Green Drive, Mobile, AL 36688-0002, United States.
Aimee M TuckerLaboratory of Molecular Biology, Department of Microbiology and Immunology, College of Medicine, University of South Alabama, 501 Aubrey Green Drive, Mobile, AL 36688-0002, United States.

Funding

GENETIC ANALYSIS OF RICKETTSIA PROWAZEKIIR37AI020384 · NIAID · UNIVERSITY OF SOUTH ALABAMA · PI WOOD, DAVID · 2000 to 2010
$3.8M
GENETIC ANALYSIS OF RICKETTSIA PROWAZEKIIR01AI020384 · NIAID · UNIVERSITY OF SOUTH ALABAMA · PI WOOD, DAVID · 1985 to 2015
$1.9M
Gene expression in stage-specific populations of Rickettsia prowazekiiR21AI103272 · NIAID · UNIVERSITY OF SOUTH ALABAMA · PI WOOD, DAVID · 2013 to 2014
$408k
Genetic Analysis of Rickettsia prowazekiiR56AI020384 · NIAID · UNIVERSITY OF SOUTH ALABAMA · PI WOOD, DAVID · 2010 to 2010
$388k
NIAID NIH HHS AI020384NIAID NIH HHS AI103272NIAID NIH HHS R01 AI020384NIAID NIH HHS R21 AI103272NIAID NIH HHS R37 AI020384NIAID NIH HHS R56 AI020384
6 · The paper itself

Abstract

Rapid advancements in the genetic manipulation of obligate intracellular bacterial pathogens have been made over the past two years. In this paper we attempt to summarize the work published since 2011 that documents these exciting accomplishments. Although each genus comprising this diverse group of pathogens poses unique problems, requiring modifications of established techniques and the introduction of new tools, all appear amenable to genetic analysis. Significantly, the field is moving forward from a focus on the identification and development of genetic techniques to their application in addressing crucial questions related to mechanisms of bacterial pathogenicity and the requirements of obligate intracellular growth.

Indexed as

Genetic TechniquesAnaplasmaBacteriological TechniquesChlamydiaGram-Negative Bacterial InfectionsHumansIntracellular SpaceRickettsia

Identifiers

PMID24581687
PMCPMC3942670

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.