Evidence map›Paper›PMID 24581672›Full record

ArticleJournal of the neurological sciences2014

Decreased physical activity predicts cognitive dysfunction and reduced cerebral blood flow in heart failure.

Michael L Alosco, Mary Beth Spitznagel, Ronald Cohen, Naftali Raz, Lawrence H Sweet, Richard Josephson, Joel Hughes, Jim Rosneck, John Gunstad

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the neurological sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 1 pooled it
17.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 1 synthesis or guideline pooled it, 64 citations in OpenAlex.

  1. Pooled it
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  7. Degree of rurality moderates the association of sedentary time with cognitive function in rural patients with cardiac diseases and depressive symptoms.The Journal of rural health : official journal of the American Rural Health Association and the National Rural Health Care Association · 2025
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  15. Impact of cardiovascular risk factors on the relationships of physical activity with mood and cognitive function in a diverse sample.Neuropsychology, development, and cognition. Section B, Aging, neuropsychology and cognition · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 1 country.

Michael L AloscoDepartment of Psychology, Kent State University, Kent, OH, USA.
Mary Beth SpitznagelDepartment of Psychology, Kent State University, Kent, OH, USA.
Ronald CohenDepartment of Neurology, University of Florida, USA; Department of Psychiatry, University of Florida, USA; The Institute on Aging, Center for Cognitive Aging and Memory, University of Florida, USA.
Naftali RazInstitute of Gerontology, Wayne State University, Detroit, MI, USA.
Lawrence H SweetDepartment of Psychology, University of Georgia, Athens, USA.
Richard JosephsonUniversity Hospitals Case Medical Center and Department of Medicine, Cleveland, OH, USA; Harrington Heart & Vascular Institute, Cleveland, OH, USA; Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Joel HughesDepartment of Psychology, Kent State University, Kent, OH, USA; Cardiac Rehabilitation, Summa Health System, Akron City Hospital, Akron, OH, USA.
Jim RosneckCardiac Rehabilitation, Summa Health System, Akron City Hospital, Akron, OH, USA.
John GunstadDepartment of Psychology, Kent State University, Kent, OH, USA. Electronic address: jgunstad@kent.edu.
Kent State University · USSumma Health System · USUniversity of Florida · USUniversity of Georgia · USUniversity School · USWayne State University · US

Funding

University of Florida Older Americans Independence Center (OAIC)P30AG028740 · NIA · UNIVERSITY OF FLORIDA · PI Peihua Qiu · 2007 to 2026
$22.8M
Neural Correlates and Modifiers of Cognitive AgingR37AG011230 · NIA · WAYNE STATE UNIVERSITY · PI RAZ, NAFTALI · 2005 to 2014
$5.2M
Cognitive Benefits of Cardiac Rehabilitation in Heart FailureR01HL089311 · NHLBI · KENT STATE UNIVERSITY · PI GUNSTAD, JOHN J. · 2008 to 2012
$2.6M
HEART DISEASE, CNS DYSFUNCTION &OUTCOME IN THE ELDERLYR01AG017975 · NIA · MIRIAM HOSPITAL · PI COHEN, RONALD A · 2000 to 2004
$1.5M
Cognitive Effects of Bariatric SurgeryR01DK075119 · NIDDK · KENT STATE UNIVERSITY · PI GUNSTAD, JOHN J. · 2006 to 2009
$1.5M
Extended Effects of Bariatric Surgery on Cognitive FunctionR56DK075119 · NIDDK · KENT STATE UNIVERSITY · PI GUNSTAD, JOHN J. · 2010 to 2010
$296k
NHLBI NIH HHS R01 HL089311NIA NIH HHS P30 AG028740NIA NIH HHS R01 AG017975NIA NIH HHS R37 AG011230NIDDK NIH HHS DK075119NIDDK NIH HHS R01 DK075119NIDDK NIH HHS R56 DK075119PHS HHS HLO89311
6 · The paper itself

Abstract

objectiveCognitive impairment in heart failure (HF) is believed to result from brain hypoperfusion subsequent to cardiac dysfunction. Physical inactivity is prevalent in HF and correlated with reduced cardiac and cognitive function. Yet, no longitudinal studies have examined the neurocognitive effects of physical inactivity in HF. The current study examined whether reduced physical activity increases risk for cognitive impairment and brain hypoperfusion over time in HF.

methodsAt baseline and 12 months later, 65 HF patients underwent neuropsychological testing, transcranial Doppler ultrasonography, and were asked to wear an accelerometer for seven days.

resultsLower baseline step count and less time spent in moderate free-living activity best predicted worse attention/executive function and decreased cerebral perfusion at the 12-month follow-up. Decreased baseline cerebral perfusion also emerged as a strong predictor of poorer 12-month attention/executive function.

conclusionsLower physical activity predicted worse cognition and cerebral perfusion 12 months later in HF. Physical inactivity in HF may contribute to cognitive impairment and exacerbate risk for conditions such as Alzheimer's disease. Larger studies are needed to elucidate the mechanisms by which physical inactivity leads to cognitive dysfunction in HF, including clarification of the role of cerebral hypoperfusion.

Indexed as

AccelerometryAgedAged, 80 and overCerebrovascular CirculationCognition DisordersFemaleFollow-Up StudiesHeart FailureHumansMaleMiddle AgedMotor ActivityNeuropsychological TestsPredictive Value of TestsProspective StudiesUltrasonography, Doppler, TranscranialAccelerometryCerebral blood flowCognitive functionHeart failureNeuropsychologyPhysical activitySedentary

Identifiers

PMID24581672
PMCPMC4009239
OpenAlexW2160251929

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.