ArticleFertility and sterility2014
Urinary cytokine and chemokine profiles across the menstrual cycle in healthy reproductive-aged women.
Article in Fertility and sterility, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 51 citations in OpenAlex.
- Effects of estrogen and progesterone on neuroactive steroids and cytokines in patients with suicidality.Psychoneuroendocrinology · 2023Trial
- Changing to a Low-Polyphenol Diet Alters Vascular Biomarkers in Healthy Men after Only Two Weeks.Nutrients · 2018Trial
- Cells, cytokines, chemokines, and cancer stress: A biobehavioral study of patients with chronic lymphocytic leukemia.Cancer · 2018Trial
- From case-control averages to validated subgroups: Interpreting inflammatory and neuroaxonal-injury biomarkers in schizophrenia and major depression.Brain, behavior, & immunity - health · 2026Review
- The Effects of Menstrual Cycle Phase on Gastrointestinal Responses to a Simulated Football Match.European journal of sport science · 2026Article
- Influence of menstrual cycle phase on inflammatory and vascular responses to acute passive heating in healthy young women.Experimental physiology · 2025Article
- Review
- Exploration of Cytokines and Microbiome Among Males and Females with Diarrhea-Predominant Irritable Bowel Syndrome.Digestive diseases and sciences · 2025Article
- A treatment algorithm for familial Mediterranean fever patients with menstruation-associated attacks.Rheumatology (Oxford, England) · 2025Article
- High-dimensional immune profiling of follicular fluid and systemic circulation reveals distinct immune signatures in women with polycystic ovary syndrome.Frontiers in immunology · 2025Article
- Fluctuations and interrelationship of oxidative stress and hepcidin during the menstrual cycle.Frontiers in endocrinology · 2025Article
- Luteal phase sertraline treatment of premenstrual dysphoric disorder (PMDD): Effects on markers of hypothalamic pituitary adrenal (HPA) axis activation and inflammation.Psychoneuroendocrinology · 2024Article
- Longitudinal associations between women's cycle characteristics and sexual motivation using Flo cycle tracking data.Scientific reports · 2024Article
- Interleukin 6 at menstruation promotes the proliferation and self-renewal of endometrial mesenchymal stromal/stem cells through the WNT/β-catenin signaling pathway.Frontiers in immunology · 2024Article
- Comparison of the cytokine responses to acute strength exercise between oral contraceptive users and naturally cycling women.European journal of applied physiology · 2024Article
- Weight Changes and Unhealthy Weight Control Behaviors Are Associated With Dysmenorrhea in Young Women.Journal of Korean medical science · 2023Article
- Association of Handgrip Strength with Diabetes Mellitus in Korean Adults According to Sex.Diagnostics (Basel, Switzerland) · 2022Article
- A contemporary understanding of iron metabolism in active premenopausal females.Frontiers in sports and active living · 2022Review
- Acupuncture Alleviates Menstrual Pain in Rat Model via Suppressing Eotaxin/CCR3 Axis to Weak EOS-MC Activation.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- Invariant Natural Killer T-cells and their subtypes may play a role in the pathogenesis of endometriosis.Clinics (Sao Paulo, Brazil) · 2022Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
objectiveTo assess the utility of urinary cytokines for monitoring reproductive function by considering detection, variation across the menstrual cycle, and relations with hormones.
designLongitudinal cohort study.
settingAcademic institution. PATIENT(S): Healthy, reproductive-aged women with self-reported regular menstrual cycles and at least one observed ovulatory cycle (n = 248). INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Urinary cytokines measured by 30-plex immunoassays in 3,550 biospecimens, and nested random-effects analysis of variance (ANOVA) and marginal structural models used to evaluate variability and relations with hormones. RESULT(S): For 24 of 30 evaluated factors, detectable levels were observed in at least 50% of urine samples. Interleukin-6 (IL-6), IL-8, IL-10, IL-15, granulocyte colony stimulating factor (G-CSF), hepatocyte growth factor (HGF), interferon-α (IFN-α), and RANTES (regulated upon activation normal T-cell expressed and secreted) levels varied significantly across the menstrual cycle. The proinflammatory factors IL-1β, IL-6, IL-8, and HGF were 1.5-3 times higher during menses than the late follicular phase. In marginal structural models, IL-1β, IL-6, IL-8 were associated with lower estradiol and progesterone concentrations. CONCLUSION(S): Variability during the menstrual cycle and correlations with reproductive hormone levels support a role of cytokines in the menstrual cycle; however, because of the limited variability for most cytokines considered, the utility of urine as a matrix for assessment of inflammation in menstrual cycle function appears limited for clinical purposes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.