Evidence map›Paper›PMID 24581578›Full record

ArticleFertility and sterility2014

Variability in the components of high-density lipoprotein particles measured in human ovarian follicular fluid: a cross-sectional analysis.

Michael S Bloom, Keewan Kim, Victor Y Fujimoto, Richard W Browne

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Fertility and sterility, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.5field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Michael S BloomDepartment of Environmental Health Sciences, University at Albany, State University of New York, Rensselaer, New York; Department of Epidemiology and Biostatistics, University at Albany, State University of New York, Rensselaer, New York. Electronic address: mbloom@albany.edu.
Keewan KimDepartment of Environmental Health Sciences, University at Albany, State University of New York, Rensselaer, New York.
Victor Y FujimotoDepartment of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco, California.
Richard W BrowneDepartment of Biotechnical and Clinical Laboratory Sciences, University at Buffalo, State University of New York, Buffalo, New York.
University at Albany, State University of New York · USUniversity at Buffalo, State University of New York · USUniversity of California, San Francisco · US

Funding

Developmental Infrastructure CoreR24HD044943 · NICHD · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI GAGE, TIMOTHY B · 2004 to 2016
$4.8M
High Density Lipoprotein (HDL) in Follicular Fluid and Fertility OutcomesR21AG031957 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FUJIMOTO, VICTOR YUTAKA · 2010 to 2011
$443k
NIA NIH HHS R21 AG031957NIA NIH HHS R21 AG031957-01A2NICHD NIH HHS R24 HD044943
6 · The paper itself

Abstract

objectiveTo assess the variability of follicular fluid (FF) high-density lipoprotein (HDL) particle components.

designCross-sectional design with assessment using two-stage nested analysis of variance.

settingReproductive health center. PATIENT(S): 180 in vitro fertilization (IVF) patients. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Nineteen HDL components including HDL cholesterol and free (unesterified) and esterified forms, phospholipids, triglycerides, apolipoproteins A-1 and A-2, paraoxonase 1 (PON1) activities, and seven lipophilic vitamins and micronutrients. RESULT(S): We collected FF specimens from two contralateral follicles on the day of oocyte retrieval and analyzed them for HDL components, characterizing the analytes by age, body mass index (BMI), race and smoking. For some analytes, a majority of total measurement variability was attributed to sources between follicles, suggesting an important role for the integrity of the blood-follicle barrier and in situ remodeling of plasma-derived constituents. For other analytes, variability was mostly attributed to sources between women, likely indicative of plasma levels. Variability between follicles decreased with increasing age and differed by BMI and smoking, and generally were lower for Asians and women with diminished ovarian reserve. CONCLUSION(S): Substantial variability in FF HDL components exist between follicles among women undergoing IVF as well as between women by age, BMI, race, smoking, and infertility diagnosis.

Indexed as

AdultBiomarkersCohort StudiesCross-Sectional StudiesFemaleFertilization in VitroFollicular FluidHumansLipoproteins, HDLOocyte RetrievalOvarian FollicleBiomarkersLipoproteins, HDLBiological variabilityfollicular fluid (FF)high density lipoprotein (HDL)infertilityin vitro fertilization (IVF)

Identifiers

PMID24581578
PMCPMC4077611
OpenAlexW1986210706

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.