ArticleBMC pulmonary medicine2014
Visualisation of time-varying respiratory system elastance in experimental ARDS animal models.
Article in BMC pulmonary medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 45 citations in OpenAlex.
- Non-invasive over-distension measurements: data driven vs model-based.Journal of clinical monitoring and computing · 2023Article
- Hypothesis-driven modeling of the human lung-ventilator system: A characterization tool for Acute Respiratory Distress Syndrome research.Journal of biomedical informatics · 2023Article
- An enhanced respiratory mechanics model based on double-exponential and fractional calculus.Frontiers in physiology · 2023Article
- Article
- Quantifying neonatal patient effort using non-invasive model-based methods.Medical & biological engineering & computing · 2022Article
- Model-based Patient Matching for in-parallel Multiplexing Mechanical Ventilation Support.IFAC-PapersOnLine · 2021Article
- Optimising mechanical ventilation through model-based methods and automation.Annual reviews in control · 2019Review
- Next-generation, personalised, model-based critical care medicine: a state-of-the art review of in silico virtual patient models, methods, and cohorts, and how to validation them.Biomedical engineering online · 2018Review
- Prediction of high airway pressure using a non-linear autoregressive model of pulmonary mechanics.Biomedical engineering online · 2017Article
- Feasibility of titrating PEEP to minimum elastance for mechanically ventilated patients.Pilot and feasibility studies · 2015Article
- Time-varying respiratory system elastance: a physiological model for patients who are spontaneously breathing.PloS one · 2015Article
- The Clinical Utilisation of Respiratory Elastance Software (CURE Soft): a bedside software for real-time respiratory mechanics monitoring and mechanical ventilation management.Biomedical engineering online · 2014Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPatients with acute respiratory distress syndrome (ARDS) risk lung collapse, severely altering the breath-to-breath respiratory mechanics. Model-based estimation of respiratory mechanics characterising patient-specific condition and response to treatment may be used to guide mechanical ventilation (MV). This study presents a model-based approach to monitor time-varying patient-ventilator interaction to guide positive end expiratory pressure (PEEP) selection.
methodsThe single compartment lung model was extended to monitor dynamic time-varying respiratory system elastance, Edrs, within each breathing cycle. Two separate animal models were considered, each consisting of three fully sedated pure pietrain piglets (oleic acid ARDS and lavage ARDS). A staircase recruitment manoeuvre was performed on all six subjects after ARDS was induced. The Edrs was mapped across each breathing cycle for each subject.
resultsSix time-varying, breath-specific Edrs maps were generated, one for each subject. Each Edrs map shows the subject-specific response to mechanical ventilation (MV), indicating the need for a model-based approach to guide MV. This method of visualisation provides high resolution insight into the time-varying respiratory mechanics to aid clinical decision making. Using the Edrs maps, minimal time-varying elastance was identified, which can be used to select optimal PEEP.
conclusionsReal-time continuous monitoring of in-breath mechanics provides further insight into lung physiology. Therefore, there is potential for this new monitoring method to aid clinicians in guiding MV treatment. These are the first such maps generated and they thus show unique results in high resolution. The model is limited to a constant respiratory resistance throughout inspiration which may not be valid in some cases. However, trends match clinical expectation and the results highlight both the subject-specificity of the model, as well as significant inter-subject variability.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.