ReviewClinical genetics2014
Strabismus genetics across a spectrum of eye misalignment disorders.
Review in Clinical genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 66 citations in OpenAlex.
- The global prevalence of horizontal strabismus: A systematic review and meta-analysis with a focus on ethnic variation.Survey of ophthalmologyPooled it
- A novel OPHN1 variant associated with cyclic strabismus but in the absence of OPHN1 syndrome.Scientific reports · 2026Article
- Genotype Association of VEGF Polymorphism rs2010963 with Strabismus in a Pakistani Cohort: A Case-Control Study.Clinical ophthalmology (Auckland, N.Z.) · 2026Article
- The global prevalence of horizontal strabismus: a systematic review and meta-analysis with a focus on ethnic variation.medRxiv : the preprint server for health sciences · 2025Article
- Whole-exome sequencing uncovers the genetic basis of hereditary concomitant exotropia in ten Chinese pedigrees.BMC medical genomics · 2025Article
- Genome-Wide Association Study with Three Control Cohorts of Japanese Patients with Esotropia and Exotropia of Comitant Strabismus and Idiopathic Superior Oblique Muscle Palsy.International journal of molecular sciences · 2024Article
- Morphometric Analysis of the Eye by Magnetic Resonance Imaging inBiomedicines · 2024Article
- Comitant strabismus etiology: extraocular muscle integrity and central nervous system involvement-a narrative review.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2023Review
- Defects and asymmetries in the visual pathway of non-human primates with natural strabismus and amblyopia.Zoological research · 2023Article
- Novel variants identified in a three‑generation family with concomitant exotropia.Experimental and therapeutic medicine · 2022Article
- Linkage analysis identifies an isolated strabismus locus at 14q12 overlapping with FOXG1 syndrome region.Journal of medical genetics · 2022Article
- Expanding the phenotypic spectrum of mutations in LRP2: a novel candidate gene of non-syndromic familial comitant strabismus.Journal of translational medicine · 2021Article
- Identification of Possible Risk Variants of Familial Strabismus Using Exome Sequencing Analysis.Genes · 2021Observational
- A commonly occurring genetic variant within the NPLOC4-TSPAN10-PDE6G gene cluster is associated with the risk of strabismus.Human genetics · 2019Article
- Involvement of dysregulated coding and long non‑coding RNAs in the pathogenesis of strabismus.Molecular medicine reports · 2018Article
- Nonhuman Primate Studies to Advance Vision Science and Prevent Blindness.ILAR journal · 2017Review
- Article
- Clinical characteristics of sibling patients with comitant strabismus.International journal of ophthalmology · 2017Article
- Article
- Altered Protein Composition and Gene Expression in Strabismic Human Extraocular Muscles and Tendons.Investigative ophthalmology & visual science · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Eye misalignment, called strabismus, is amongst the most common phenotypes observed, occurring in up to 5% of individuals in a studied population. While misalignment is frequently observed in rare complex syndromes, the majority of strabismus cases are non-syndromic. Over the past decade, genes and pathways associated with syndromic forms of strabismus have emerged, but the genes contributing to non-syndromic strabismus remain elusive. Genetic testing for strabismus risk may allow for earlier diagnosis and treatment, as well as decreased frequency of surgery. We review human and model organism literature describing non-syndromic strabismus, including family, twin, linkage, and gene expression studies. Recent advances in the genetics of Duane retraction syndrome are considered, as relatives of those impacted show elevated familial rates of non-syndromic strabismus. As whole genome sequencing efforts are advancing for the discovery of the elusive strabismus genes, this overview is intended to support the interpretation of the new findings.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.