ArticleIranian Red Crescent medical journal2013
Antimicrobial susceptibility of clostridium difficile clinical isolates in iran.
Article in Iranian Red Crescent medical journal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 3 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
46 citing papers in PubMed, 3 syntheses or guidelines pooled it, 93 citations in OpenAlex.
- Pooled it
- Antimicrobial resistance in Clostridioides (Clostridium) difficile derived from humans: a systematic review and meta-analysis.Antimicrobial resistance and infection control · 2020Pooled it
- The prevalence of antibiotic-resistant Clostridium species in Iran: a meta-analysis.Pathogens and global health · 2019Pooled it
- Clostridioides difficile pathogenesis and control.Nature reviews. Microbiology · 2026Review
- Current and Ongoing Developments in TargetingMicroorganisms · 2024Review
- Antibiotic Resistances of Clostridioides difficile.Advances in experimental medicine and biology · 2024Article
- Characterization of Food ChainMicroorganisms · 2023Article
- Systematic Review and Meta-Analysis on the Frequency of Antibiotic-ResistantAntibiotics (Basel, Switzerland) · 2022Review
- Loop mediated isothermal amplification of Clostridioides difficile isolates in gastrointestinal patients.AMB Express · 2022Article
- Emergence of Clinical Clostridioides difficile Isolates With Decreased Susceptibility to Vancomycin.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2022Article
- Toxin gene profiles and antimicrobial resistance ofIranian journal of microbiology · 2021Article
- 2'FL and LNnT Exert Antipathogenic Effects againstPathogens (Basel, Switzerland) · 2021Article
- Temporal Variations in Patterns ofAntibiotics (Basel, Switzerland) · 2021Article
- Inhibition of Quinolone- and Multi-Drug-Resistant Clostridioides Difficile Strains by Multi Strain Synbiotics-An Option for Diarrhea Management in Nursing Facilities.International journal of environmental research and public health · 2021Article
- Molecular Epidemiology and Antimicrobial Resistance ofFrontiers in microbiology · 2021Article
- Phenotypical and Genotypical Comparison ofThe Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2021Article
- Frequency of toxin genes and antibiotic resistance pattern ofGastroenterology and hepatology from bed to bench · 2021Article
- Clinical and microbial characterization of toxigenicIranian journal of microbiology · 2020Article
- Article
- Plasmid-mediated metronidazole resistance in Clostridioides difficile.Nature communications · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundClostridium difficile infection (CDI) is major growing problem in hospitals and its high incidence has been reported in recent years.
objectivesThe aim of this study was to investigate the antimicrobial susceptibility patterns of C. difficile clinical isolates against antibiotics commonly used for treatment CDI in hospitalized patients. MATERIAL AND
methodsDuring a 12 month study, 75 C. difficile isolates were collected from 390 patients with CDI. All samples were treated with alcohol and yeast extract broth. The treated suspensions were cultured on a selective cycloserine cefoxitin fructose agar (CCFA) supplemented with 5% sheep blood and incubated in anaerobic conditions, at 37 °C for 5 days. Cdd-3, tcdA and tcdB genes were identified using PCR assay.
resultsThe prevalence of A(+)B(+) , A(+) B(-) and A(-) B(+) strains were 64(85.3%), 5(6.7%) and 6(8%) respectively. In vitro susceptibility of 75 clinical isolates of C. difficile to 5 antimicrobial agents, including metronidazole, vancomycin, clindamycin, erythromycin and cefotaxime were investigated by Clinical and Laboratory Standards Institute (CLSI) agar dilution method. Metronidazole and vancomycin had good activity against C. difficile isolates with MIC90s of 2 and 1 µg/ml, respectively. Seventy one (94.6%) of strains was inhibited by concentrations that did not exceed 2µg/ml for metronidazole. Resistant to metronidazole observed in 5.3% of isolates. Forty three (57.3%) of the isolates were resistant to erythromycin. Of 43 resistant strains to erythromycin, 9 (12%) isolates had high-level MIC of more than 64 µg/ml. All strains were resistant to cefotaxime. Sixty seven (89.3%) isolates were resistant to clindamycin (MIC90s > 256 µg/ml) and only 6.7% were sensitive to clindamycin. Multidrug-resistant (three or more antibiotics) was seen in 36(48%) isolates.
conclusionsMetronidazole and vancomycin still seem to be most effective drugs for treatment CDI.
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