ArticleJournal of dental research, dental clinics, dental prospects2013
In Vitro Cytotoxicity Assessment of an Orthodontic Composite Containing Titanium-dioxide Nano-particles.
Article in Journal of dental research, dental clinics, dental prospects, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The trial behind it
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Who cites it
23 citing papers in PubMed, 43 citations in OpenAlex.
- Evaluation of Nano TiOBiological trace element research · 2023Trial
- Enhanced penetration and antibacterial efficacy of calcium hydroxide modified with titanium dioxide nanoparticles.Scientific reports · 2025Article
- Review
- Influence of final irrigation with titanium dioxide and silver nanoparticles on the fracture resistance of endodontically treated roots.The Saudi dental journal · 2024Article
- Quantitative determination and antibacterial properties of TiO2 nanoparticle-doped glass ionomer cement: an in vitro study.European oral research · 2024Article
- Effect of natural silk fibers and synthetic fiber-reinforced composites on the cytotoxicity of fibroblast cell lines.Journal of dental research, dental clinics, dental prospects · 2024Article
- Antibacterial Properties and Shear Bond Strength of Titanium Dioxide Nanoparticles Incorporated into an Orthodontic Adhesive: A Systematic Review.International journal of clinical pediatric dentistry · 2024Review
- Comparative Evaluation of TiONanomaterials (Basel, Switzerland) · 2023Article
- Review
- Biocompatibility of several colloidal solutions containing nanoparticles on human gingival fibroblasts.Dental research journal · 2021Article
- Prospects of nanodentistry for the diagnosis and treatment of maxillofacial pathologies and cancers.Heliyon · 2020Review
- The effect of silver nanoparticles, zinc oxide nanoparticles, and titanium dioxide nanoparticles on the push-out bond strength of fiber posts.Journal of clinical and experimental dentistry · 2020Article
- The Effects of Silver, Zinc Oxide, and Titanium Dioxide Nanoparticles Used as Dentin Pretreatments on the Microshear Bond Strength of a Conventional Glass Ionomer Cement to Dentin.International journal of nanomedicine · 2020Article
- The Effect of Silver, Zinc Oxide, and Titanium Dioxide Nanoparticles Used as Final Irrigation Solutions on the Fracture Resistance of Root-Filled Teeth.Clinical, cosmetic and investigational dentistry · 2020Article
- Spectrophotometric Analysis of Dental Enamel Staining to Antiseptic and Dietary Agents: In Vitro Study.International journal of dentistry · 2020Article
- Shear bond strength and adhesive remnant index of orthodontic brackets bonded to enamel using adhesive systems mixed with TiO2 nanoparticles.Dental press journal of orthodontics · 2018Article
- Interaction of New-Developed TiO₂-Based Photocatalytic Nanoparticles with Pathogenic Microorganisms and Human Dermal and Pulmonary Fibroblasts.International journal of molecular sciences · 2017Article
- Cytotoxicity of Selected Nanoparticles on Human Dental Pulp Stem Cells.Iranian endodontic journal · 2017Article
- The staining effect of different mouthwashes containing nanoparticles on dental enamel.Journal of clinical and experimental dentistry · 2015Article
- Nanotechnology and its application in dentistry.Annals of medical and health sciences research · 2014Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and aims. Incorporation of nano-particles to orthodontic bonding systems has been considered to prevent enamel demineralization around appliances. This study investigated cytotoxicity of Transbond XT adhesive containing 1 wt% titanium dioxide (TiO2) nano-particles. Materials and methods. Ten composite disks were prepared from each of the conventional and TiO2-containg composites and aged for 1, 3, 5, 7 and 14 days in Dulbecco's Modified Eagle's Medium (DMEM). The extracts were obtained and exposed to culture media of human gingival fibroblasts (HGF) and mouse L929 fibroblasts. Cell viability was measured using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Results. Both adhesives were moderately toxic for HGF cells on the first day of the experiment, but the TiO2-containing adhesive produced significantly lower toxicity than the pure adhesive (P<0.05). No significant differences were found in cell viability percentages between the two groups on the other days (P>0.05). There was a significant reduction in cell toxicity with increasing pre-incubation time (P<0.001). L929 cells showed similar toxicity trends, but lower sensitivity to detect cytotoxicity of dental composites. Conclusion. The orthodontic adhesive containing TiO2 nano-particles indicated comparable or even lower toxicity than its nano-particle-free counterpart, indicating that incorporation of 1 wt% TiO2 nano-particles to the composite structure does not result in additional health hazards compared to that occurring with the pure adhesive.
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Registered trials
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