ArticleFrontiers in neuroscience2014
Therapeutic intraspinal stimulation to generate activity and promote long-term recovery.
Article in Frontiers in neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Neural Stimulation and Molecular Mechanisms of Plasticity and Regeneration: A Review.Frontiers in cellular neuroscience · 2020Pooled it
- Olfactory Ensheathing Cell Transplantation Combined With Electrical Epidural Stimulation as a Long-Term Treatment for Severe Spinal Cord Injury in Female Fischer 344 Rats.The European journal of neuroscience · 2026Article
- A Hyperflexible Electrode Array for Long-Term Recording and Decoding of Intraspinal Neuronal Activity.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Optogenetic spinal stimulation promotes new axonal growth and skilled forelimb recovery in rats with sub-chronic cervical spinal cord injury.Journal of neural engineering · 2023Article
- Corticospinal interface to restore voluntary control of joint torque in a paralyzed forearm following spinal cord injury in non-human primates.Frontiers in neuroscience · 2023Article
- Epidural oscillating field stimulation increases axonal regenerative capacity and myelination after spinal cord trauma.Neural regeneration research · 2022Article
- Respiratory plasticity following spinal cord injury: perspectives from mouse to man.Neural regeneration research · 2022Review
- Review
- A wireless spinal stimulation system for ventral activation of the rat cervical spinal cord.Scientific reports · 2021Article
- Spinal Interneurons as Gatekeepers to Neuroplasticity after Injury or Disease.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Review
- Neuroregeneration and functional recovery after stroke: advancing neural stem cell therapy toward clinical application.Neural regeneration research · 2021Article
- Evidence of axon connectivity across a spinal cord transection in rats treated with epidural stimulation and motor training combined with olfactory ensheathing cell transplantation.Experimental neurology · 2018Article
- Now is the Critical Time for Engineered Neuroplasticity.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2018Review
- Development of an Activity-Dependent Epidural Stimulation System in Freely Moving Spinal Cord Injured Rats: A Proof of Concept Study.Frontiers in neuroscience · 2018Article
- High-frequency epidural stimulation across the respiratory cycle evokes phrenic short-term potentiation after incomplete cervical spinal cord injury.Journal of neurophysiology · 2017Article
- Regenerative Rehabilitation: Combining Stem Cell Therapies and Activity-Dependent Stimulation.Pediatric physical therapy : the official publication of the Section on Pediatrics of the American Physical Therapy Association · 2017Article
- Electrical neuromodulation of the cervical spinal cord facilitates forelimb skilled function recovery in spinal cord injured rats.Experimental neurology · 2017Article
- Intraspinal microstimulation produces over-ground walking in anesthetized cats.Journal of neural engineering · 2016Article
- Rebuilding motor function of the spinal cord based on functional electrical stimulation.Neural regeneration research · 2016Article
- Neural prostheses for restoring functions lost after spinal cord injury.Neural regeneration research · 2015Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Neuroprosthetic approaches have tremendous potential for the treatment of injuries to the brain and spinal cord by inducing appropriate neural activity in otherwise disordered circuits. Substantial work has demonstrated that stimulation applied to both the central and peripheral nervous system leads to immediate and in some cases sustained benefits after injury. Here we focus on cervical intraspinal microstimulation (ISMS) as a promising method of activating the spinal cord distal to an injury site, either to directly produce movements or more intriguingly to improve subsequent volitional control of the paretic extremities. Incomplete injuries to the spinal cord are the most commonly observed in human patients, and these injuries spare neural tissue bypassing the lesion that could be influenced by neural devices to promote recovery of function. In fact, recent results have demonstrated that therapeutic ISMS leads to modest but sustained improvements in forelimb function after an incomplete spinal cord injury (SCI). This therapeutic spinal stimulation may promote long-term recovery of function by providing the necessary electrical activity needed for neuron survival, axon growth, and synaptic stability.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.