ArticleAdvanced functional materials2013
Regulation of Stem Cell Fate in a Three-Dimensional Micropatterned Dual-Crosslinked Hydrogel System.
Article in Advanced functional materials, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Tough PEGDA-Based Bioadhesive Hydrogels for High-Strength In Situ Cartilage Adhesion.ACS omega · 2025Article
- Immunomodulatory Delivery Materials for Tissue Repair.Advanced healthcare materials · 2025Review
- Integrating Deep Learning and Real-Time Imaging to Visualize In Situ Self-Assembly of Self-Healing Interpenetrating Polymer Networks Formed by Protein and Polysaccharide Fibers.ACS applied materials & interfaces · 2025Article
- Stiff Hydrogel Encapsulation Retains Mesenchymal Stem Cell Stemness for Regenerative Medicine.Matter · 2024Article
- Stem Cell-Based Tissue Engineering Approaches for Diabetic Foot Ulcer: a Review from Mechanism to Clinical Trial.Stem cell reviews and reports · 2024Review
- Innovations in Stem Cell Therapy for Diabetic Wound Healing.Advances in wound care · 2023Review
- Stem cell-laden hydrogel bioink for generation of high resolution and fidelity engineered tissues with complex geometries.Bioactive materials · 2022Article
- Strategies for improving adipose-derived stem cells for tissue regeneration.Burns & trauma · 2022Review
- Reversible dynamic mechanics of hydrogels for regulation of cellular behavior.Acta biomaterialia · 2021Article
- The Use of Microfabrication Techniques for the Design and Manufacture of Artificial Stem Cell Microenvironments for Tissue Regeneration.Bioengineering (Basel, Switzerland) · 2021Review
- Modeling the Tumor Microenvironment and Pathogenic Signaling in Bone Sarcoma.Tissue engineering. Part B, Reviews · 2020Review
- Bioprinters for organs-on-chips.Biofabrication · 2019Review
- Cryopreserved cell-laden alginate microgel bioink for 3D bioprinting of living tissues.Materials today. Chemistry · 2019Article
- Hydrogel Biomaterials for Stem Cell Microencapsulation.Polymers · 2018Review
- Spatial Micropatterning of Growth Factors in 3D Hydrogels for Location-Specific Regulation of Cellular Behaviors.Small (Weinheim an der Bergstrasse, Germany) · 2018Article
- Enhanced bioactivity and osteoinductivity of carboxymethyl chitosan/nanohydroxyapatite/graphene oxide nanocomposites.RSC advances · 2018Article
- Generation of spatial-patterned early-developing cardiac organoids using human pluripotent stem cells.Nature protocols · 2018Article
- Current Advancements and Strategies in Tissue Engineering for Wound Healing: A Comprehensive Review.Advances in wound care · 2017Review
- The effect of RGD peptide on 2D and miniaturized 3D culture of HEPM cells, MSCs, and ADSCs with alginate hydrogel.Cellular and molecular bioengineering · 2016Article
- Dual-crosslinked hydrogel microwell system for formation and culture of multicellular human adipose tissue-derived stem cell spheroids.Journal of materials chemistry. B · 2016Article
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2 authors.
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Abstract
Micropatterning technology is a powerful tool for controlling the cellular microenvironment and investigating the effects of physical parameters on cell behaviors, such as migration, proliferation, apoptosis, and differentiation. Although there have been significant developments in regulating the spatial and temporal distribution of physical properties in various materials, little is known about the role of the size of micropatterned regions of hydrogels with different crosslinking densities on the response of encapsulated cells. In this study, novel alginate hydrogel system is engineered that can be micropatterned three-dimensionally to create regions that are crosslinked by a single mechanism or dual mechanisms. By manipulating micropattern size while keeping the overall ratio of single- to dual-crosslinked hydrogel volume constant, the physical properties of the micropatterned alginate hydrogels are spatially tunable. When human adipose-derived stem cells (hASCs) are photoencapsulated within micropatterned hydrogels, their proliferation rate is a function of micropattern size. Additionally, micropattern size dictates the extent of osteogenic and chondrogenic differentiation of photoencapsulated hASC. The size of 3D micropatterned physical properties in this new hydrogel system introduces a new design parameter for regulating various cellular behaviors, and this dual-crosslinked hydrogel system provides a new platform for studying proliferation and differentiation of stem cells in a spatially controlled manner for tissue engineering and regenerative medicine applications.
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