Evidence map›Paper›PMID 24578648›Full record

Trial reportTheScientificWorldJournal2014

Effects of dietary milled seed mixture on fatty acid status and inflammatory markers in patients on hemodialysis.

Danijela Ristic-Medic, Gordana Perunicic-Pekovic, Zorica Rasic-Milutinovic, Marija Takic, Tamara Popovic, Aleksandra Arsic, Marija Glibetic

Registry-linked trialOpen access · goldAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in TheScientificWorldJournal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03260231 (Effects of Dietary Milled Seed Mix in Patients With Non-Hodgkin Lymphoma), which is not on this map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03260231 naunknown statusnot on this mapstarted 2017, after this paper: background citation

Effects of Dietary Milled Seed Mix in Patients With Non-Hodgkin Lymphoma

TypeinterventionalSponsorUniversity of BelgradeRan2017 to 2021Enrolled40ConditionsNon-hodgkin LymphomaArmsMilled seed mix
3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Review
  9. Nitric Oxide as a Determinant of Human Longevity and Health Span.International journal of molecular sciences · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Danijela Ristic-MedicCentre of Research Excellence in Nutrition and Metabolism, Institute for Medical Research, University of Belgrade, P.O. Box 102, 11000 Belgrade, Serbia.ORCID 0000-0002-7041-4220
Gordana Perunicic-PekovicDepartment of Nephrology and Dialysis, Clinical Hospital Zemun, University of Belgrade, Belgrade, Serbia.
Zorica Rasic-MilutinovicDepartment of Endocrinology, Diabetes and Metabolism, Clinical Hospital Zemun, University of Belgrade, Belgrade, Serbia.ORCID 0000-0001-9381-1977
Marija TakicCentre of Research Excellence in Nutrition and Metabolism, Institute for Medical Research, University of Belgrade, P.O. Box 102, 11000 Belgrade, Serbia.
Tamara PopovicCentre of Research Excellence in Nutrition and Metabolism, Institute for Medical Research, University of Belgrade, P.O. Box 102, 11000 Belgrade, Serbia.
Aleksandra ArsicCentre of Research Excellence in Nutrition and Metabolism, Institute for Medical Research, University of Belgrade, P.O. Box 102, 11000 Belgrade, Serbia.
Marija GlibeticCentre of Research Excellence in Nutrition and Metabolism, Institute for Medical Research, University of Belgrade, P.O. Box 102, 11000 Belgrade, Serbia.
University of Belgrade · RS

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPlant seeds have gained interest for their health benefits due to their fatty acid content. The objective of this study was to determine the effects of dietary consumption of milled sesame/pumpkin/flax seed mixture on glycemic control, serum lipids, phospholipid fatty acid status, and inflammatory factors in patients on hemodialysis.

methodsThirty patients with well nutrition status (18 male, 12 female) were enrolled in the study. Participants consumed 30 g of milled sesame/pumpkin/flax (6 g/6 g/18 g, resp.) seeds mixture added to their habitual diet.

resultsTotal n-6 and n-3 polyunsaturated fatty acids and levels of linoleic, dihomo-gamma-linolenic (DGLA), arachidonic, alpha-linolenic (ALA), eicosapentaenoic, docosapentaenoic, and docosahexaenoic (DHA) acid were increased after 12 weeks of supplementation. A significant decrease of the serum triglyceride level (P < 0.001), glucose, insulin, calculated IR HOMA (P < 0.05), and inflammatory markers (TNF-alpha, IL-6, and hs-CRP, P < 0.001) was observed after seed mixture treatment. The serum levels of CRP and TNF-alpha negative correlate with ALA, DHA, and DGLA.

conclusionResults of this study indicated that dietary milled sesame/pumpkin/flax seed mixture added to a habitual diet lowered triglyceride and CRP, TNF-alpha, IL-6 levels, affect glycemic control and improved fatty acid profile and pruritus symptoms in hemodialysis patients.

Indexed as

Dietary SupplementsRenal DialysisAdultBiomarkersBlood GlucoseCross-Sectional StudiesCucurbitaFatty AcidsFemaleFlaxFollow-Up StudiesHumansInsulinInterleukin-6MaleMiddle AgedBiomarkersBlood GlucoseFatty AcidsInsulinInterleukin-6Triglycerides

Identifiers

PMID24578648
PMCPMC3919090
OpenAlexW2049242662

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.