Evidence map›Paper›PMID 24578612›Full record

ArticleInternational journal of medical sciences2014

The relationships between thyroid hormones and thyroid-stimulating hormone with lipid profile in euthyroid men.

Kok-Yong Chin, Soelaiman Ima-Nirwana, Isa Naina Mohamed, Amilia Aminuddin, Mohamad Hanapi Johari, Wan Zurinah Wan Ngah

Open access · goldAbstract read
In one paragraph

Article in International journal of medical sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.

  1. Pooled it
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  9. Observational
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  14. Hypothyroidism and Lipid Levels in a Community Based Study (TTS).International journal of endocrinology and metabolism · 2016
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Kok-Yong Chin1. Pharmacology Department, Faculty of Medicine, Universiti Kebangsaan Malaysia.
Soelaiman Ima-Nirwana1. Pharmacology Department, Faculty of Medicine, Universiti Kebangsaan Malaysia.
Isa Naina Mohamed1. Pharmacology Department, Faculty of Medicine, Universiti Kebangsaan Malaysia.
Amilia Aminuddin2. Physiology Department, Faculty of Medicine, Universiti Kebangsaan Malaysia.
Mohamad Hanapi Johari3. Biochemistry Department, Faculty of Medicine, Universiti Kebangsaan Malaysia.
Wan Zurinah Wan Ngah3. Biochemistry Department, Faculty of Medicine, Universiti Kebangsaan Malaysia. ; 4. UKM Medical Molecular Biology Institute (UMBI), Universiti Kebangsaan Malaysia.
National University of Malaysia · MYUniversity Kebangsaan Malaysia Medical Centre · MY

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimAlteration in lipid profile is a common observation in patients with thyroid dysfunction, but the current knowledge on the relationship between lipids and thyroid hormone levels in euthyroid state is insufficient. The current study aimed to determine the association between thyroid hormones and thyroid-stimulating hormone (TSH) with lipid profile in a euthyroid male population.

methodsA total of 708 Chinese and Malay men aged 20 years and above were recruited in this cross-sectional study. Their blood was collected for the determination of total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), triglyceride (TG), free thyroxine (FT4), free triiodothyronine (FT3) and TSH levels. The association was analyzed using multiple regression and logistic regression models with adjustment for age, ethnicity, body mass index and FT4/FT3/TSH levels.

resultsIn multiple regression models, TSH was positively and significantly associated with TG (p<0.05). Free T4 was positively and significantly associated with TC, LDL-C and HDL-C (p<0.05). Free T3 was negatively and significantly associated with HDL-C (p<0.05). In binary logistic models, an increase in TSH was significantly associated with higher prevalence of elevated TG in the subjects (p<0.05), while an increase in FT4 was significantly associated with higher prevalence of elevated TC but a lower prevalence of subnormal HDL in the subjects (p<0.05). Free T3 was not associated with any lipid variables in the logistic regression (p>0.05).

conclusionsIn euthyroid Malaysian men, there are positive and significant relationships between TSH level and TG level, and between FT4 level and cholesterol levels.

Indexed as

AdultCholesterolCholesterol, HDLCholesterol, LDLCross-Sectional StudiesFemaleHumansLipidsMaleMiddle AgedThyroid HormonesThyrotropinThyroxineTriglyceridesTriiodothyronineCholesterolCholesterol, HDLCholesterol, LDLLipidsThyroid HormonesThyrotropinThyroxineTriglyceridesTriiodothyronineCholesterolMenThyroid hormonesThyroid-stimulating hormoneTriglycerides.

Identifiers

PMID24578612
PMCPMC3936029
OpenAlexW2159752632

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.