ArticleClinical journal of the American Society of Nephrology : CJASN2014
Heritability of urinary traits that contribute to nephrolithiasis.
Article in Clinical journal of the American Society of Nephrology : CJASN, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Association of vitamin D receptor gene polymorphisms and risk of urolithiasis: results of a genetic epidemiology study and comprehensive meta-analysis.Urolithiasis · 2020Pooled it
- The effects of elevated phosphate on the kidney - damaging the gatekeeper.Pflugers Archiv : European journal of physiology · 2026Review
- Genetic and Clinical Characterization of a Large Cohort with Suspected Monogenic Stone Disease.Clinical journal of the American Society of Nephrology : CJASN · 2025Article
- Genetic drivers of age-related changes in urinary magnesium excretion.Physiological genomics · 2024Article
- Monogenic features of urolithiasis: A comprehensive review.Asian journal of urology · 2024Review
- Replacing a kidney biopsy by exome sequencing in undetermined kidney diseases-not yet ready for prime time!Clinical kidney journal · 2024Article
- Article
- Skeletal and extraskeletal disorders of biomineralization.Nature reviews. Endocrinology · 2022Review
- Evaluation of Genetic Kidney Diseases in Living Donor Kidney Transplantation: Towards Precision Genomic Medicine in Donor Risk Assessment.Current transplantation reports · 2022Article
- The genetics of kidney stone disease and nephrocalcinosis.Nature reviews. Nephrology · 2022Review
- Animal models of naturally occurring stone disease.Nature reviews. Urology · 2020Review
- Low urine pH predicts new onset of diabetes mellitus during a 10-year period in men: BOREAS-DM1 study.Journal of diabetes investigation · 2020Article
- Rare genetic causes of complex kidney and urological diseases.Nature reviews. Nephrology · 2020Review
- Evidence for disordered acid-base handling in calcium stone-forming patients.American journal of physiology. Renal physiology · 2020Article
- Genome-wide Association Study of 24-Hour Urinary Excretion of Calcium, Magnesium, and Uric Acid.Mayo Clinic proceedings. Innovations, quality & outcomes · 2019Article
- Association between vitamin D receptor gene polymorphisms and idiopathic hypocitraturia in a Chinese Bai population.Urolithiasis · 2019Article
- Classical and Modern Genetic Approach to Kidney Stone Disease.Kidney international reports · 2019Article
- Urinary proteome in inherited nephrolithiasis.Urolithiasis · 2019Review
- Heritable traits that contribute to nephrolithiasis.Urolithiasis · 2019Review
- Confounding risk factors and preventative measures driving nephrolithiasis global makeup.World journal of nephrology · 2018Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
BACKGROUND AND
objectivesKidney stones and their risk factors aggregate in families, yet few studies have systematically estimated heritabilities and genetic correlations of the numerous urinary traits associated with risk of kidney stones. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Twenty-four-hour urine samples were collected from the Genetic Epidemiology Network of Arteriopathy cohort of families in Rochester, Minnesota, to measure urinary determinants of supersaturation. Diet was assessed using the Viocare food frequency questionnaire. Heritabilities and genetic correlations among the urinary traits were estimated using variance components methods.
resultsSamples were available from 811 individuals (344 men, 467 women; mean age 66 ± 9 years). Age, sex, and weight were significantly correlated with the majority of urinary traits. Many urine excretions (calcium, magnesium, citrate excretion) had strong evidence for heritability (P<0.01) both before and after adjusting for the identified covariates. Among significantly heritable urinary traits, genetic factors explained 20%-36% of interindividual variation after adjustment for covariates. Urinary calcium excretion was significantly genetically correlated with urinary magnesium and with urinary citrate excretion (P<0.05). Although eGFR influenced many urinary traits, controlling for eGFR did not greatly affect estimated heritabilities.
conclusionsEvidence from this cohort suggests a strong heritable component to many urinary nephrolithiasis risk factors. Further study of genetic influences on urinary traits relevant for kidney stone pathogenesis is warranted.
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